Hypoxia. 4. Hypoxia and ion channel function

Larissa Shimoda, Jan Polak

Research output: Contribution to journalArticle

Abstract

The ability to sense and respond to oxygen deprivation is required for survival; thus, understanding the mechanisms by which changes in oxygen are linked to cell viability and function is of great importance. Ion channels play a critical role in regulating cell function in a wide variety of biological processes, including neuronal transmission, control of ventilation, cardiac contractility, and control of vasomotor tone. Since the 1988 discovery of oxygen-sensitive potassium channels in chemoreceptors, the effect of hypoxia on an assortment of ion channels has been studied in an array of cell types. In this review, we describe the effects of both acute and sustained hypoxia (continuous and intermittent) on mammalian ion channels in several tissues, the mode of action, and their contribution to diverse cellular processes.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Cell Physiology
Volume300
Issue number5
DOIs
StatePublished - May 2011

Fingerprint

Ion Channels
Oxygen
Biological Phenomena
Potassium Channels
Ventilation
Cell Survival
Hypoxia

Keywords

  • Mammalian ion channels
  • Oxygen deprivation
  • Oxygen homeostasis

ASJC Scopus subject areas

  • Cell Biology
  • Physiology

Cite this

Hypoxia. 4. Hypoxia and ion channel function. / Shimoda, Larissa; Polak, Jan.

In: American Journal of Physiology - Cell Physiology, Vol. 300, No. 5, 05.2011.

Research output: Contribution to journalArticle

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