Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) trial

H. Nida Sen; Lea T. Drye; Debra A. Goldstein; Theresa A. Larson; Pauline T. Merrill; Peter R. Pavan; John D. Sheppard; Alyce Burke; Sunil K. Srivastava; Douglas A. Jabs

doi:10.3109/09273948.2011.647228

Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) trial

H. Nida Sen, Lea T. Drye, Debra A. Goldstein, Theresa A. Larson, Pauline T. Merrill, Peter R. Pavan, John D. Sheppard, Alyce Burke, Sunil K. Srivastava, Douglas A. Jabs

Bloomberg School of Public Health

Research output: Contribution to journal › Article

Abstract

Purpose: To assess the prevalence of hypotony in patients with severe forms of uveitis. Methods: The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified. Results: Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis ≥5 years duration (odds ratio [OR]=5.0; p <.01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR=3.1; p=.03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. <51 years, OR=0.1; p=.02), in Caucasian patients (OR=0.1; p <.01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR=22.9; p <.01). Conclusions: Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.

Original language	English (US)
Pages (from-to)	104-112
Number of pages	9
Journal	Ocular Immunology and Inflammation
Volume	20
Issue number	2
DOIs	https://doi.org/10.3109/09273948.2011.647228
State	Published - Apr 1 2012

Keywords

Hypotony
Multicenter uveitis steroid treatment trial
Uveitis
Visual impairment
Visual loss

ASJC Scopus subject areas

Immunology and Allergy
Ophthalmology

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Sen, H. N., Drye, L. T., Goldstein, D. A., Larson, T. A., Merrill, P. T., Pavan, P. R., Sheppard, J. D., Burke, A., Srivastava, S. K., & Jabs, D. A. (2012). Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) trial. Ocular Immunology and Inflammation, 20(2), 104-112. https://doi.org/10.3109/09273948.2011.647228

Hypotony in patients with uveitis : The Multicenter Uveitis Steroid Treatment (MUST) trial. / Sen, H. Nida; Drye, Lea T.; Goldstein, Debra A.; Larson, Theresa A.; Merrill, Pauline T.; Pavan, Peter R.; Sheppard, John D.; Burke, Alyce; Srivastava, Sunil K.; Jabs, Douglas A.

In: Ocular Immunology and Inflammation, Vol. 20, No. 2, 01.04.2012, p. 104-112.

Research output: Contribution to journal › Article

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