Hypothyroidism in transgenic mice expressing IFN-γ in the thyroid

Patrizio P Caturegli, M. Hejazi, K. Suzuki, O. Dohan, N. Carrasco, L. D. Kohn, N. R. Rose

Research output: Contribution to journalArticle

Abstract

IFN-γ has been implicated with contradictory results in the pathogenetic process of autoimmune (Hashimoto's) thyroiditis, the most common cause of hypothyroidism in adults. To test whether the local production of IFN-γ can lead to thyroid dysfunction, we have generated transgenic mice that express constitutively IFN-γ in the thyroid follicular cells. This expression resulted in severe hypothyroidism, with growth retardation and disruption of the thyroid architecture. The hypothyroidism derived from a profound inhibition of the expression of the sodium iodide symporter gene. Taken together, these results indicate a direct role of IFN-γ in the thyroid dysfunction that occurs in autoimmune thyroiditis.

Original languageEnglish (US)
Pages (from-to)1719-1724
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number4
DOIs
StatePublished - Feb 15 2000

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Hypothyroidism
Transgenic Mice
Autoimmune Thyroiditis
Thyroid Gland
Hashimoto Disease
Growth
Genes

ASJC Scopus subject areas

  • Genetics
  • General

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Hypothyroidism in transgenic mice expressing IFN-γ in the thyroid. / Caturegli, Patrizio P; Hejazi, M.; Suzuki, K.; Dohan, O.; Carrasco, N.; Kohn, L. D.; Rose, N. R.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 4, 15.02.2000, p. 1719-1724.

Research output: Contribution to journalArticle

Caturegli, Patrizio P ; Hejazi, M. ; Suzuki, K. ; Dohan, O. ; Carrasco, N. ; Kohn, L. D. ; Rose, N. R. / Hypothyroidism in transgenic mice expressing IFN-γ in the thyroid. In: Proceedings of the National Academy of Sciences of the United States of America. 2000 ; Vol. 97, No. 4. pp. 1719-1724.
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