@article{737ae58a6983433d99aa5bc296739ddf,
title = "Hypothesis: Wound-induced TLR3 activation stimulates endogenous retinoic acid synthesis and signalling during regeneration",
abstract = "Although the mechanism is unclear, it has been shown that genetically normal adult mice with a large wound form de novo morphogenesis of hair follicles in wound-induced hair neogenesis (WIHN)(1). We focused on how tissues recognize damage signals and identified that double-stranded RNA (dsRNA)-mediated toll-like receptor 3 (TLR3) activation stimulates WIHN. Here, we propose a hypothesis that TLR3 stimulates retinoic acid synthesis and signalling to allow for regeneration, suggesting that common clinical methods of facial rejuvenation in human subjects through damage (such as lasers or dermabrasion), and the use of topical retinoids reflect the same biologic pathway.",
author = "Dongwon Kim and Garza, {Luis A.}",
note = "Funding Information: National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR068280, R01AR064297), U.S. Department of Defense (18‐2‐0055, W81XWH‐16‐C‐0167) and DK is also supported by Maryland stem cell research fund (2017‐MSCRFF‐3905). Funding Information: Both DK and LAG generated the ideas and wrote this Hypothesis Letter. Figure was created by both DK and LAG. LAG is sup‐ ported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health, under R01AR064297 and AR068280 to LAG. This work was also sup‐ ported by the Department of Defense, Armed Forces Institute of Regenerative Medicine, Extremities Regeneration (AFIRM2‐ ER11), CDMRMP W81XWH‐16‐C‐0167 and 18‐2‐0055. DK is financially supported by Maryland Stem Cell Research Fund (2017‐MSCRFF‐3905). Publisher Copyright: {\textcopyright} 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2019",
month = apr,
doi = "10.1111/exd.13931",
language = "English (US)",
volume = "28",
pages = "450--452",
journal = "Experimental Dermatology",
issn = "0906-6705",
publisher = "Wiley-Blackwell",
number = "4",
}