Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

Jessica N Cooke Bailey, Brian L. Yaspan, Louis R. Pasquale, Michael A. Hauser, Jae H. Kang, Stephanie J. Loomis, Murray Brilliant, Donald L. Budenz, William G. Christen, John Fingert, Douglas Gaasterland, Terry Gaasterland, Peter Kraft, Richard K. Lee, Paul R. Lichter, Yutao Liu, Catherine A. McCarty, Sayoko E. Moroi, Julia E. Richards, Tony RealiniJoel S. Schuman, William K. Scott, Kuldev Singh, Arthur J. Sit, Douglas Vollrath, Gadi Wollstein, Donald J Zack, Kang Zhang, Margaret A. Pericak-Vance, R. Rand Allingham, Robert N. Weinreb, Jonathan L. Haines, Janey L. Wiggs

Research output: Contribution to journalArticle

Abstract

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. Using genome-wide association single-nucleotide polymorphism data from the Glaucoma Genes and Environment study and National Eye Institute Glaucoma Human Genetics Collaboration comprising 3,108 cases and 3,430 controls, we assessed biologic pathways as annotated in the KEGG database for association with risk of POAG. After correction for genic overlap among pathways, we found 4 pathways, butanoate metabolism (hsa00650), hematopoietic cell lineage (hsa04640), lysine degradation (hsa00310) and basal transcription factors (hsa03022) related to POAG with permuted p 

Original languageEnglish (US)
Pages (from-to)1319-1330
Number of pages12
JournalHuman Genetics
Volume133
Issue number10
DOIs
StatePublished - 2014

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Acetyl Coenzyme A
Glaucoma
gamma-Aminobutyric Acid
Pressure
National Eye Institute (U.S.)
Medical Genetics
Cell Lineage
Blindness
Lysine
Single Nucleotide Polymorphism
Transcription Factors
Genome
Databases
Genes
Primary Open Angle Glaucoma

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Bailey, J. N. C., Yaspan, B. L., Pasquale, L. R., Hauser, M. A., Kang, J. H., Loomis, S. J., ... Wiggs, J. L. (2014). Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. Human Genetics, 133(10), 1319-1330. https://doi.org/10.1007/s00439-014-1468-7

Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. / Bailey, Jessica N Cooke; Yaspan, Brian L.; Pasquale, Louis R.; Hauser, Michael A.; Kang, Jae H.; Loomis, Stephanie J.; Brilliant, Murray; Budenz, Donald L.; Christen, William G.; Fingert, John; Gaasterland, Douglas; Gaasterland, Terry; Kraft, Peter; Lee, Richard K.; Lichter, Paul R.; Liu, Yutao; McCarty, Catherine A.; Moroi, Sayoko E.; Richards, Julia E.; Realini, Tony; Schuman, Joel S.; Scott, William K.; Singh, Kuldev; Sit, Arthur J.; Vollrath, Douglas; Wollstein, Gadi; Zack, Donald J; Zhang, Kang; Pericak-Vance, Margaret A.; Allingham, R. Rand; Weinreb, Robert N.; Haines, Jonathan L.; Wiggs, Janey L.

In: Human Genetics, Vol. 133, No. 10, 2014, p. 1319-1330.

Research output: Contribution to journalArticle

Bailey, JNC, Yaspan, BL, Pasquale, LR, Hauser, MA, Kang, JH, Loomis, SJ, Brilliant, M, Budenz, DL, Christen, WG, Fingert, J, Gaasterland, D, Gaasterland, T, Kraft, P, Lee, RK, Lichter, PR, Liu, Y, McCarty, CA, Moroi, SE, Richards, JE, Realini, T, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Vollrath, D, Wollstein, G, Zack, DJ, Zhang, K, Pericak-Vance, MA, Allingham, RR, Weinreb, RN, Haines, JL & Wiggs, JL 2014, 'Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma', Human Genetics, vol. 133, no. 10, pp. 1319-1330. https://doi.org/10.1007/s00439-014-1468-7
Bailey, Jessica N Cooke ; Yaspan, Brian L. ; Pasquale, Louis R. ; Hauser, Michael A. ; Kang, Jae H. ; Loomis, Stephanie J. ; Brilliant, Murray ; Budenz, Donald L. ; Christen, William G. ; Fingert, John ; Gaasterland, Douglas ; Gaasterland, Terry ; Kraft, Peter ; Lee, Richard K. ; Lichter, Paul R. ; Liu, Yutao ; McCarty, Catherine A. ; Moroi, Sayoko E. ; Richards, Julia E. ; Realini, Tony ; Schuman, Joel S. ; Scott, William K. ; Singh, Kuldev ; Sit, Arthur J. ; Vollrath, Douglas ; Wollstein, Gadi ; Zack, Donald J ; Zhang, Kang ; Pericak-Vance, Margaret A. ; Allingham, R. Rand ; Weinreb, Robert N. ; Haines, Jonathan L. ; Wiggs, Janey L. / Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. In: Human Genetics. 2014 ; Vol. 133, No. 10. pp. 1319-1330.
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AU - Hauser, Michael A.

AU - Kang, Jae H.

AU - Loomis, Stephanie J.

AU - Brilliant, Murray

AU - Budenz, Donald L.

AU - Christen, William G.

AU - Fingert, John

AU - Gaasterland, Douglas

AU - Gaasterland, Terry

AU - Kraft, Peter

AU - Lee, Richard K.

AU - Lichter, Paul R.

AU - Liu, Yutao

AU - McCarty, Catherine A.

AU - Moroi, Sayoko E.

AU - Richards, Julia E.

AU - Realini, Tony

AU - Schuman, Joel S.

AU - Scott, William K.

AU - Singh, Kuldev

AU - Sit, Arthur J.

AU - Vollrath, Douglas

AU - Wollstein, Gadi

AU - Zack, Donald J

AU - Zhang, Kang

AU - Pericak-Vance, Margaret A.

AU - Allingham, R. Rand

AU - Weinreb, Robert N.

AU - Haines, Jonathan L.

AU - Wiggs, Janey L.

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