TY - JOUR
T1 - Hypothermia for neuroprotection after cardiac arrest
T2 - Mechanisms, clinical trials and patient care
AU - Froehler, Michael T.
AU - Geocadin, Romergryko G.
N1 - Funding Information:
Dr. Geocadin was supported in part by NIH Grants R01-HL071568 and R21-NS42690.
PY - 2007/10/15
Y1 - 2007/10/15
N2 - Therapeutic hypothermia is a proven part of cardio-cerebral resuscitation after cardiac arrest as it improves neurologic outcomes after hypoxic brain injury. This article reviews the mechanisms of hypothermic neuroprotection, the clinical trials that support its use after cardiac arrest, as well as the impact of hypothermia on patient management and prognosis. In caring for patients suffering hypoxic brain injury after cardiac arrest, the role of the neurologist is no longer limited to prognosis but is now to become actively involved in clinical management which includes the use of therapeutic hypothermia.
AB - Therapeutic hypothermia is a proven part of cardio-cerebral resuscitation after cardiac arrest as it improves neurologic outcomes after hypoxic brain injury. This article reviews the mechanisms of hypothermic neuroprotection, the clinical trials that support its use after cardiac arrest, as well as the impact of hypothermia on patient management and prognosis. In caring for patients suffering hypoxic brain injury after cardiac arrest, the role of the neurologist is no longer limited to prognosis but is now to become actively involved in clinical management which includes the use of therapeutic hypothermia.
KW - Cardiac arrest
KW - Cardiovascular disease
KW - Cerebral perfusion
KW - Coma
KW - Hypothermia
KW - Prognosis
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U2 - 10.1016/j.jns.2007.04.042
DO - 10.1016/j.jns.2007.04.042
M3 - Article
C2 - 17559883
AN - SCOPUS:34548157918
SN - 0022-510X
VL - 261
SP - 118
EP - 126
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -