Hypothalamic nutrient sensing and energy balance

Research output: Chapter in Book/Report/Conference proceedingChapter


Hypothalamic neurons have the capacity to sense and alter their activity in response to fluctuations in local nutrient concentrations. Alterations in glucose, fatty acid and amino acid concentrations have all been demonstrated to affect neuronal excitability and/or intracellular signaling pathways. The degree to which such changes in nutrient availability have the capacity to modify energy balance varies across nutrient type. The underlying mechanisms through which various nutrients affect food intake and overall energy balance involve both specific and shared neuronal substrates.

Original languageEnglish (US)
Title of host publicationFrontiers in Eating and Weight Regulation
EditorsNori Geary, Wolfgang Langhans
Number of pages8
StatePublished - Sep 6 2010

Publication series

NameForum of Nutrition
ISSN (Print)1660-0347


ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Moran, T. H. (2010). Hypothalamic nutrient sensing and energy balance. In N. Geary, & W. Langhans (Eds.), Frontiers in Eating and Weight Regulation (pp. 94-101). (Forum of Nutrition; Vol. 63). https://doi.org/10.1159/000264397