Hypotension following patent ductus arteriosus ligation: The role of adrenal hormones

Ronald I. Clyman, Andrea Wickremasinghe, T. Allen Merritt, Tabitha Solomon, Patrick McNamara, Amish Jain, Jaideep Singh, Alison Chu, Shahab Noori, Krishnamurthy Sekar, Pascal M. Lavoie, Joshua T. Attridge, Jonathan R. Swanson, Maria Gillam-Krakauer, Jeff Reese, Sara Demauro, Brenda Poindexter, Sue Aucott, Monique Satpute, Erika FernandezRichard J. Auchus

Research output: Contribution to journalArticlepeer-review


Objective To test the hypothesis that an impaired adrenal response to stress might play a role in the hypotension that follows patent ductus arteriosus (PDA) ligation. Study design We performed a multicenter study of infants born at <32 weeks' gestation who were about to undergo PDA ligation. Serum adrenal steroids were measured 3 times: before and after a cosyntropin (1.0 μg/kg) stimulation test (performed before the ligation), and at 10-12 hours after the ligation. A standardized approach for diagnosis and treatment of postoperative hypotension was followed at each site. A modified inotrope score (1 × dopamine [μg/kg/min] + 1 × dobutamine) was used to monitor the catecholamine support an infant received. Infants were considered to have catecholamine-resistant hypotension if their greatest inotrope score was >15. Results Of 95 infants enrolled, 43 (45%) developed hypotension and 14 (15%) developed catecholamine-resistant hypotension. Low postoperative cortisol levels were not associated with the overall incidence of hypotension after ligation. However, low cortisol levels were associated with the refractoriness of the hypotension to catecholamine treatment. In a multivariate analysis: the OR for developing catecholamine-resistant hypotension was OR 36.6, 95% CI 2.8-476, P =.006. Low cortisol levels (in infants with catecholamine-resistant hypotension) were not attributable to adrenal immaturity or impairment; their cortisol precursor concentrations were either low or unchanged, and their response to cosyntropin was similar to infants without catecholamine-resistant hypotension. Conclusion Infants with low cortisol concentrations after PDA ligation are likely to develop postoperative catecholamine-resistant hypotension. We speculate that decreased adrenal stimulation, rather than an impaired adrenal response to stimulation, may account for the decreased production.

Original languageEnglish (US)
Pages (from-to)1449-1455.e1
JournalJournal of Pediatrics
Issue number6
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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