Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury

Daijiro Hori, Masahiro Ono, Thomas E. Rappold, John V. Conte, Ashish S. Shah, Duke E. Cameron, Hideo Adachi, Allen D Everett, Charles W. Hogue

Research output: Contribution to journalArticle

Abstract

Background. Individualizing blood pressure targets could improve organ perfusion compared with current practices. In this study we assess whether hypotension defined by cerebral autoregulation monitoring vs standard definitions is associated with elevation in the brain-specific injury biomarker glial fibrillary acidic protein plasma levels (GFAP). Methods. Plasma GFAP levels were measured in 121 patients undergoing cardiac operations after anesthesia induction, at the conclusion of the operation, and on postoperative day 1. Cerebral autoregulation was monitored during the operation with the cerebral oximetry index, which correlates low-frequency changes in mean arterial pressure (MAP) and regional cerebral oxygen saturation. Blood pressure was recorded every 15 minutes in the intensive care unit. Hypotension was defined based on autoregulation data as an MAP below the optimal MAP (MAP at the lowest cerebral oximetry index) and based on standard definitions (systolic blood pressure decrement >20%, >30% from baseline, or

Original languageEnglish (US)
Pages (from-to)487-493
Number of pages7
JournalAnnals of Thoracic Surgery
Volume100
Issue number2
DOIs
StatePublished - Aug 1 2015

Fingerprint

Hypotension
Brain Injuries
Arterial Pressure
Homeostasis
Blood Pressure
Oximetry
Glial Fibrillary Acidic Protein
Intensive Care Units
Blood Proteins
Anesthesia
Perfusion
Biomarkers
Oxygen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Hori, D., Ono, M., Rappold, T. E., Conte, J. V., Shah, A. S., Cameron, D. E., ... Hogue, C. W. (2015). Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury. Annals of Thoracic Surgery, 100(2), 487-493. https://doi.org/10.1016/j.athoracsur.2015.03.036

Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury. / Hori, Daijiro; Ono, Masahiro; Rappold, Thomas E.; Conte, John V.; Shah, Ashish S.; Cameron, Duke E.; Adachi, Hideo; Everett, Allen D; Hogue, Charles W.

In: Annals of Thoracic Surgery, Vol. 100, No. 2, 01.08.2015, p. 487-493.

Research output: Contribution to journalArticle

Hori, D, Ono, M, Rappold, TE, Conte, JV, Shah, AS, Cameron, DE, Adachi, H, Everett, AD & Hogue, CW 2015, 'Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury', Annals of Thoracic Surgery, vol. 100, no. 2, pp. 487-493. https://doi.org/10.1016/j.athoracsur.2015.03.036
Hori, Daijiro ; Ono, Masahiro ; Rappold, Thomas E. ; Conte, John V. ; Shah, Ashish S. ; Cameron, Duke E. ; Adachi, Hideo ; Everett, Allen D ; Hogue, Charles W. / Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury. In: Annals of Thoracic Surgery. 2015 ; Vol. 100, No. 2. pp. 487-493.
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