Hypomethylation of ras oncogenes in primary human cancers

Research output: Contribution to journalArticlepeer-review

Abstract

We have examined the methylation status of two cellular oncogenes, c-Ha-ras and c-Ki-ras, in primary human carcinomas and the adjacent analogous normal tissues from which the tumors derived. The c-Ha-ras gene was hypomethylated in six of eight carcinomas, including five colonic adenocarcinomas and one small cell lung carcinoma, when compared to adjacent normal tissues. The c-Ki-ras gene was hypomethylated to a lesser extent in two colonic adenocarcinomas. This is the first demonstration of alterations in methylation of cellular oncogenes in human cancer.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume111
Issue number1
DOIs
StatePublished - Feb 28 1983

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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