Hypoglycemia due to surreptitious injection of insulin: Identification of insulin species by high-performance liquid chromatography

Bruce D. Given, Diane M. Ostrega, Kenneth S. Polonsky, David Baldwin, Richard I. Kelley, Arthur H. Rubenstein

Research output: Contribution to journalArticle

Abstract

Objective: To identify the circulating species of insulin after separation by high-performance liquid chromatography (HPLC) in patients with factitious hypoglycemia. Research Design and Methods: In three of four patients presented, the diagnosis of surreptitious insulin injection was made by documenting the presence of animal insulin in the circulation after separation of the circulating insulin forms by HPLC. Results: Animal insulin was identified. Conclusions: Thus, the identification of the circulating form of insulin in the circulation by HPLC may be a useful adjunct in the diagnosis of factitious hypoglycemia if animal insulin has been injected and if the simultaneously measured concentrations of insulin and C-peptide are inconclusive.

Original languageEnglish (US)
Pages (from-to)544-547
Number of pages4
JournalDiabetes care
Volume14
Issue number7
DOIs
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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    Given, B. D., Ostrega, D. M., Polonsky, K. S., Baldwin, D., Kelley, R. I., & Rubenstein, A. H. (1991). Hypoglycemia due to surreptitious injection of insulin: Identification of insulin species by high-performance liquid chromatography. Diabetes care, 14(7), 544-547. https://doi.org/10.2337/diacare.14.7.544