Hypogammaglobulinemia in children undergoing continuous ambulatory peritoneal dialysis

Barbara A. Fivush, Barbara Case, Michael W. May, Howard M. Lederman

Research output: Contribution to journalArticle

Abstract

Humoral immunity was evaluated in seven children undergoing continuous ambulatory peritoneal dialysis (CAPD). Five children (71%) had serum immunoglobulin levels which were more than 2 SD below the mean for age. One mechanism contributing to hypogammaglobulinemia was loss via the peritoneal membrane. Daily losses of IgG into peritoneal dialysis effluents represented 7%-29% of normal daily IgG synthesis, and losses increased with duration of CAPD therapy. Despite the observed hypogammaglobulinemia, all children had protective antibody responses to immunization.

Original languageEnglish (US)
Pages (from-to)186-188
Number of pages3
JournalPediatric Nephrology
Volume3
Issue number2
DOIs
StatePublished - Jun 1 1989

Keywords

  • Humoral immunity
  • Hypogammaglobulinemia
  • Peritoneal dialysis
  • Protein loss

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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