Hypocapnia does not alter collateral ventilation in sheep

B. B. Hudak, Peter Browne Terry, H. A. Menkes, M. D. Jones, R. J. Traystman

Research output: Contribution to journalArticle

Abstract

Hypocapnic constriction has been proposed as a mechanism by which collateral pathways might rapidly alter ventilation to match perfusion. We studied the changes in response to hypocapnia with age in sheep, a species with collateral resistances (Rcoll) similar to those measured in humans. Measurements of Rcoll were made with either 5 or 10% CO2 and with air (hypocapnia) in 29 anesthetized sheep, ages 6 mo to 10 yr, with the wedged bronchoscope technique. Rcoll was 0.42 ± 0.12, 0.58 ± 0.18, 0.32 ± 0.18, and 0.17 ± 0.04 (SE) cmH2O · ml-1 · min in 6-mo- and 1-, 2-, and 10-yr-old animals, respectively. These values were unchanged with hypocapnia. Despite the lack of a change in Rcoll with hypocapnia, administration of histamine aerosol (8 animals) through the bronchoscope increased Rcoll by 151 ± 35% (P <0.05). These data suggest that although collateral pathways exist in sheep and are capable of constriction, they do not respond to hypocapnia. Furthermore, the response to hypocapnia is not influenced by age.

Original languageEnglish (US)
Pages (from-to)503-507
Number of pages5
JournalJournal of Applied Physiology
Volume68
Issue number2
StatePublished - 1990

Fingerprint

Hypocapnia
Ventilation
Sheep
Bronchoscopes
Constriction
Aerosols
Histamine
Perfusion
Air

Keywords

  • development/maturation
  • histamine
  • ventilation-perfusion imbalance

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hudak, B. B., Terry, P. B., Menkes, H. A., Jones, M. D., & Traystman, R. J. (1990). Hypocapnia does not alter collateral ventilation in sheep. Journal of Applied Physiology, 68(2), 503-507.

Hypocapnia does not alter collateral ventilation in sheep. / Hudak, B. B.; Terry, Peter Browne; Menkes, H. A.; Jones, M. D.; Traystman, R. J.

In: Journal of Applied Physiology, Vol. 68, No. 2, 1990, p. 503-507.

Research output: Contribution to journalArticle

Hudak, BB, Terry, PB, Menkes, HA, Jones, MD & Traystman, RJ 1990, 'Hypocapnia does not alter collateral ventilation in sheep', Journal of Applied Physiology, vol. 68, no. 2, pp. 503-507.
Hudak BB, Terry PB, Menkes HA, Jones MD, Traystman RJ. Hypocapnia does not alter collateral ventilation in sheep. Journal of Applied Physiology. 1990;68(2):503-507.
Hudak, B. B. ; Terry, Peter Browne ; Menkes, H. A. ; Jones, M. D. ; Traystman, R. J. / Hypocapnia does not alter collateral ventilation in sheep. In: Journal of Applied Physiology. 1990 ; Vol. 68, No. 2. pp. 503-507.
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