Hypoattenuating myocardium

Imaging description Diseases affecting the myocardium, including myocardial infarction (MI), are generally better seen on electrocardiographically gated cardiac CT and cardiac MRI. However, signs of recent or prior MI such as myocardial hypoperfusion, lipomatous metaplasia, wall thinning, aneurysm formation, myocardial calcification, and left ventricular thrombus may be found incidentally on conventional (non-gated) CT performed for non-cardiac indications.Although the myocardium is usually not well resolved on non-gated studies due to cardiac motion blurring, perfusion abnormalities secondary to myocardial ischemia may be occasionally detected as incidental findings (Figure 41.1). Detection of these abnormalities is dependent on acquisition during the period of optimal myocardial enhancement, which occurs in the late arterial phase. Consequently, these abnormalities may be missed on early arterial phase CT timed for the evaluation of pulmonary embolism. Even in the setting of optimal acquisition timing, care should be taken in diagnosis as false positive results due to beam hardening artifacts from adjacent bones can simulate a perfusion abnormality. In such cases, multiplanar reconstructions may help in assessing if these apparent perfusion defects match vascular territories (Figure 41.1). Subendocardial fat from lipomatous metaplasia, a marker for chronic MI that is frequently identified on non-gated CT examinations, may sometimes mimic an area of perfusion abnormality due to its low attenuation on contrast-enhanced images (Figure 41.2). However, unlike perfusion abnormalities, lipomatous metaplasia will be visible on noncontrast CT examinations. In addition, the presence of fat in the subendocardium can be confirmed by using a region of interest to measure average Hounsfield units, which should be less than zero.ImportanceMyocardial infarction is usually better seen on cardiac gated CT and cardiac MRI. However, conventional CT performed to evaluate non-cardiac causes of chest pain may have important clues suggestive of acute or chronic MI that could suggest a cardiac etiology for the patient's pain Typical clinical scenario Patients presenting with acute chest pain with suspicion of pulmonary embolism may get a non-gated chest CT for evaluation. CT may demonstrate presence of subendocardial perfusion abnormality in an anatomic distribution of a coronary artery, highly suggestive of MI.