Hyperzincemia in anencephaly and spina bifida: A clue to the pathogenesis of neural tube defects?

Andrew W. Zimmerman

Research output: Contribution to journalArticlepeer-review

Abstract

Zinc is essential for normal embryogenesis and may have particular importance for closure of the human neural tube. Compared to 258 controls, we found increased zinc content in umbilical cord serum in eight of nine newborn anencephalics (p <0.02) and three infants with spina bifida (p <0.001). Increased zinc levels were bound to serum albumin or alpha-2-macroglobulin (α2M) in infants with neural tube defects (NTD). In NTD-mothers, total serum zinc was similar to controls, but there was a shift in the distribution of zinc from α2M to albumin. Fetal hyperzincemia and elevated maternal albumin-bound zinc suggest that the NTD-fetus receives but does not use zinc normally.

Original languageEnglish (US)
Pages (from-to)443-450
Number of pages8
JournalNeurology
Volume34
Issue number4
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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