TY - JOUR
T1 - Hypertrophic olivary degeneration in a child following midbrain tumor resection
T2 - Longitudinal diffusion tensor imaging studies - Case report
AU - Orman, Gunes
AU - Bosemani, Thangamadhan
AU - Jallo, George I.
AU - Huisman, Thierry A.G.M.
AU - Poretti, Andrea
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/4
Y1 - 2014/4
N2 - Hypertrophic olivary degeneration (HOD) is a dynamic process caused by disruptive lesions affecting componentsof the Guillain-Mollaret triangle (GMT). The authors applied diffusion tensor imaging (DTI) to investigatelongitudinal changes of the GMT components in a child with HOD after neurosurgery for a midbrain tumor.Diffusiontensor imaging data were acquired on a 1.5-T MRI scanner using a balanced pair of diffusion gradients along20 noncollinear directions 1 day and 3, 6, and 9 months after surgery. Measurements from regions of interest (ROIs)were sampled in the affected inferior olivary nucleus, ipsilateral red nucleus, and contralateral superior and inferiorcerebellar peduncles and dentate nucleus. For each ROI, fractional anisotropy and the mean, axial, and radial diffusivitieswere calculated. In the affected inferior olivary nucleus, the authors found a decrease in fractional anisotropyand an increase in mean, axial, and radial diffusivities 3 months after surgery, while 3 months later fractionalanisotropy increased and diffusivities decreased. For all other GMT components, changes in DTI scalars were lesspronounced, and fractional anisotropy mildly decreased over time. A detailed analysis of longitudinal DTI scalars inthe various GMT components may shed light on a better understanding of the dynamic complex histopathologicalprocesses occurring in pediatric HOD over time.
AB - Hypertrophic olivary degeneration (HOD) is a dynamic process caused by disruptive lesions affecting componentsof the Guillain-Mollaret triangle (GMT). The authors applied diffusion tensor imaging (DTI) to investigatelongitudinal changes of the GMT components in a child with HOD after neurosurgery for a midbrain tumor.Diffusiontensor imaging data were acquired on a 1.5-T MRI scanner using a balanced pair of diffusion gradients along20 noncollinear directions 1 day and 3, 6, and 9 months after surgery. Measurements from regions of interest (ROIs)were sampled in the affected inferior olivary nucleus, ipsilateral red nucleus, and contralateral superior and inferiorcerebellar peduncles and dentate nucleus. For each ROI, fractional anisotropy and the mean, axial, and radial diffusivitieswere calculated. In the affected inferior olivary nucleus, the authors found a decrease in fractional anisotropyand an increase in mean, axial, and radial diffusivities 3 months after surgery, while 3 months later fractionalanisotropy increased and diffusivities decreased. For all other GMT components, changes in DTI scalars were lesspronounced, and fractional anisotropy mildly decreased over time. A detailed analysis of longitudinal DTI scalars inthe various GMT components may shed light on a better understanding of the dynamic complex histopathologicalprocesses occurring in pediatric HOD over time.
KW - Children
KW - Diffusion tensor imaging
KW - Guillain-Mollaret triangle
KW - Hypertrophic olivary degeneration
KW - Inferior olivary nucleus
KW - Magnetic resonance imaging
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U2 - 10.3171/2014.1.PEDS13490
DO - 10.3171/2014.1.PEDS13490
M3 - Article
C2 - 24527860
AN - SCOPUS:84897932435
SN - 1933-0707
VL - 13
SP - 408
EP - 413
JO - Journal of Neurosurgery: Pediatrics
JF - Journal of Neurosurgery: Pediatrics
IS - 4
ER -