Abstract
The use of HS solutions has been shown to reduce ICP both in animal models and in human studies in a variety of underlying disorders, even in cases refractory to treatment with hyperventilation and mannitol. There are several possible mechanisms of action, and important complications such as central pontine myelinolysis and intracranial hemorrhage have not been reported in the human studies. Different types of HS solutions with different methods of infusion (bolus and continuous) have been used in the past, and so far there are not enough data to recommend one concentration over another. Many issues remain to be clarified, including the exact mechanism of action of HS, the best mode of administration and HS concentration to be given, and the relative efficacy of HS vis-á-vis available treatments, particularly mannitol.
| Original language | English (US) |
|---|---|
| Journal | Cleveland Clinic Journal of Medicine |
| Volume | 71 |
| Issue number | SUPPL.1 |
| DOIs | |
| State | Published - Dec 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Hypertonic saline for cerebral edema and elevated intracranial pressure. / Suarez, Jose.
In: Cleveland Clinic Journal of Medicine, Vol. 71, No. SUPPL.1, 01.12.2003.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypertonic saline for cerebral edema and elevated intracranial pressure
AU - Suarez, Jose
PY - 2003/12/1
Y1 - 2003/12/1
N2 - The use of HS solutions has been shown to reduce ICP both in animal models and in human studies in a variety of underlying disorders, even in cases refractory to treatment with hyperventilation and mannitol. There are several possible mechanisms of action, and important complications such as central pontine myelinolysis and intracranial hemorrhage have not been reported in the human studies. Different types of HS solutions with different methods of infusion (bolus and continuous) have been used in the past, and so far there are not enough data to recommend one concentration over another. Many issues remain to be clarified, including the exact mechanism of action of HS, the best mode of administration and HS concentration to be given, and the relative efficacy of HS vis-á-vis available treatments, particularly mannitol.
AB - The use of HS solutions has been shown to reduce ICP both in animal models and in human studies in a variety of underlying disorders, even in cases refractory to treatment with hyperventilation and mannitol. There are several possible mechanisms of action, and important complications such as central pontine myelinolysis and intracranial hemorrhage have not been reported in the human studies. Different types of HS solutions with different methods of infusion (bolus and continuous) have been used in the past, and so far there are not enough data to recommend one concentration over another. Many issues remain to be clarified, including the exact mechanism of action of HS, the best mode of administration and HS concentration to be given, and the relative efficacy of HS vis-á-vis available treatments, particularly mannitol.
UR - http://www.scopus.com/inward/record.url?scp=84884585159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884585159&partnerID=8YFLogxK
U2 - 10.3949/ccjm.71.Suppl_1.S9
DO - 10.3949/ccjm.71.Suppl_1.S9
M3 - Article
C2 - 14964472
AN - SCOPUS:84884585159
VL - 71
JO - Cleveland Clinic Journal of Medicine
JF - Cleveland Clinic Journal of Medicine
SN - 0891-1150
IS - SUPPL.1
ER -