Hypertonic saline: First-line therapy for cerebral edema?

Wendy C. Ziai; Thomas J.K. Toung; Anish Bhardwaj

doi:10.1016/j.jns.2007.04.048

Hypertonic saline: First-line therapy for cerebral edema?

Wendy C. Ziai, Thomas J.K. Toung, Anish Bhardwaj

School of Medicine

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

This article highlights the experimental and clinical data, controversies and postulated mechanisms surrounding osmotherapy with hypertonic saline (HS) solutions in the neurocritical care arena and builds on previous reviews on the subject. Special attention is focused on HS therapy on commonly encountered clinical paradigms of acute brain injury including traumatic brain injury (TBI), post-operative "retraction edema", intracranial hemorrhage (ICH), tumor-associated cerebral edema, and ischemia associated with ischemic stroke.

Original language	English (US)
Pages (from-to)	157-166
Number of pages	10
Journal	Journal of the Neurological Sciences
Volume	261
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2007.04.048
State	Published - Oct 15 2007

Keywords

Cerebral edema
Hypertonic saline
Intracranial hemorrhage

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.jns.2007.04.048

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title = "Hypertonic saline: First-line therapy for cerebral edema?",

abstract = "This article highlights the experimental and clinical data, controversies and postulated mechanisms surrounding osmotherapy with hypertonic saline (HS) solutions in the neurocritical care arena and builds on previous reviews on the subject. Special attention is focused on HS therapy on commonly encountered clinical paradigms of acute brain injury including traumatic brain injury (TBI), post-operative {"}retraction edema{"}, intracranial hemorrhage (ICH), tumor-associated cerebral edema, and ischemia associated with ischemic stroke.",

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author = "Ziai, {Wendy C.} and Toung, {Thomas J.K.} and Anish Bhardwaj",

note = "Funding Information: This work is supported in part by the Clinical Research Training Fellowship Award from the American Academy of Neurology (WCZ) and US Public Health Service National Institutes of Health grant NS046379 (AB, TJKT).",

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AB - This article highlights the experimental and clinical data, controversies and postulated mechanisms surrounding osmotherapy with hypertonic saline (HS) solutions in the neurocritical care arena and builds on previous reviews on the subject. Special attention is focused on HS therapy on commonly encountered clinical paradigms of acute brain injury including traumatic brain injury (TBI), post-operative "retraction edema", intracranial hemorrhage (ICH), tumor-associated cerebral edema, and ischemia associated with ischemic stroke.

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KW - Intracranial hemorrhage

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Hypertonic saline: First-line therapy for cerebral edema?

Abstract

Keywords

ASJC Scopus subject areas

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