Hyperthermia and hypermetabolism in focal cerebral ischemia

Edwin M. Nemoto, Charles Jungreis, Donald Larnard, Hiroto Kuwabara, Michael Horowitz, Amin Kassam

Research output: Contribution to journalArticle

Abstract

The reliable and reproducible creation of an animal model of focal cerebral ischemia is not easily accomplished. Using a transortibal approach, we showed that occlusion of the posterior cerebral artery (PCA), middle cerebral artery (MCA), and the contralateral anterior cerebral artery (ACA) created a large cortical and subcortical stroke in the non-human primate (NHP). Subsequently, we created the same stroke endovascularly in the NHP. Using the endovascular stroke model in the NHP, we measured brain temperature with thermocouples and cerebral blood flow (CBF) by stable xenon CT in one NHP, and CMRO2 and CBF by positron emission tomography (PET) in another NHP. Two female non-human primates (M. mulatta) weighing 7.0 and 8.0 kg, respectively, were studied under fentanyl-diazepam anesthesia with continuous monitoring of arterial blood pressure, rectal temperature, and end-tidal CO2 with intermittent blood gas measurements. Using an endovascular approach, the PCA (P2), MCA (M1), and the ICA at the bifurcation and contralateral ACA produced a large hemispheric stroke. In the right ischemic hemisphere, temperatures increased by 2°C-3°C. PET measurement of CBF and CMRO2 showed that CMRO2 increased in the region of the ischemic stroke. We found that both hyperthermia and hypermetabolism occur in acute stroke.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalAdvances in experimental medicine and biology
Volume566
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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