TY - JOUR
T1 - Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
AU - the All of Us Research Program Investigators
AU - Chandler, Paulette D.
AU - Clark, Cheryl R.
AU - Zhou, Guohai
AU - Noel, Nyia L.
AU - Achilike, Confidence
AU - Mendez, Lizette
AU - Ramirez, Andrea H.
AU - Loperena-Cortes, Roxana
AU - Mayo, Kelsey
AU - Cohn, Elizabeth
AU - Ohno-Machado, Lucila
AU - Boerwinkle, Eric
AU - Cicek, Mine
AU - Qian, Jun
AU - Schully, Sheri
AU - Ratsimbazafy, Francis
AU - Mockrin, Stephen
AU - Gebo, Kelly
AU - Dedier, Julien J.
AU - Murphy, Shawn N.
AU - Smoller, Jordan W.
AU - Karlson, Elizabeth W.
AU - Ahsan, Habibul
AU - Ajayi, Toluwalase
AU - Alonso, Alvaro
AU - Arora, Amit
AU - Aschebrook-Kilfoy, Briseis
AU - Baxter, Sally L.
AU - Billheimer, Dean
AU - Bleeker, Eugene R.
AU - Bonomi, Luca
AU - Carrasquillo, Olveen
AU - Chen, Qingxia
AU - Chesla, Dave
AU - Craver, Andrew
AU - Dastur, Zubin
AU - Study/PRIDEnet, The Pride
AU - Ehiri, John
AU - Epstein, Mara M.
AU - Feng, Xiaoke
AU - Flentje, Annesa
AU - Project, Alliance Health
AU - Garber, Lawrence
AU - Giangreco, Nicholas
AU - Guo, Yi
AU - Hiatt, Robert A.
AU - Ho, Kai Yin
AU - Ho, Joyce
AU - Hogan, William
AU - Hripcsak, George
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - The All of Us Research Program was designed to enable broad-based precision medicine research in a cohort of unprecedented scale and diversity. Hypertension (HTN) is a major public health concern. The validity of HTN data and definition of hypertension cases in the All of Us (AoU) Research Program for use in rule-based algorithms is unknown. In this cross-sectional, population-based study, we compare HTN prevalence in the AoU Research Program to HTN prevalence in the 2015–2016 National Health and Nutrition Examination Survey (NHANES). We used AoU baseline data from patient (age ≥ 18) measurements (PM), surveys, and electronic health record (EHR) blood pressure measurements. We retrospectively examined the prevalence of HTN in the EHR cohort using Systemized Nomenclature of Medicine (SNOMED) codes and blood pressure medications recorded in the EHR. We defined HTN as the participant having at least 2 HTN diagnosis/billing codes on separate dates in the EHR data AND at least one HTN medication. We calculated an age-standardized HTN prevalence according to the age distribution of the U.S. Census, using 3 groups (18–39, 40–59, and ≥ 60). Among the 185,770 participants enrolled in the AoU Cohort (mean age at enrollment = 51.2 years) available in a Researcher Workbench as of October 2019, EHR data was available for at least one SNOMED code from 112,805 participants, medications for 104,230 participants, and 103,490 participants had both medication and SNOMED data. The total number of persons with SNOMED codes on at least two distinct dates and at least one antihypertensive medication was 33,310 for a crude prevalence of HTN of 32.2%. AoU age-adjusted HTN prevalence was 27.9% using 3 groups compared to 29.6% in NHANES. The AoU cohort is a growing source of diverse longitudinal data to study hypertension nationwide and develop precision rule-based algorithms for use in hypertension treatment and prevention research. The prevalence of hypertension in this cohort is similar to that in prior population-based surveys.
AB - The All of Us Research Program was designed to enable broad-based precision medicine research in a cohort of unprecedented scale and diversity. Hypertension (HTN) is a major public health concern. The validity of HTN data and definition of hypertension cases in the All of Us (AoU) Research Program for use in rule-based algorithms is unknown. In this cross-sectional, population-based study, we compare HTN prevalence in the AoU Research Program to HTN prevalence in the 2015–2016 National Health and Nutrition Examination Survey (NHANES). We used AoU baseline data from patient (age ≥ 18) measurements (PM), surveys, and electronic health record (EHR) blood pressure measurements. We retrospectively examined the prevalence of HTN in the EHR cohort using Systemized Nomenclature of Medicine (SNOMED) codes and blood pressure medications recorded in the EHR. We defined HTN as the participant having at least 2 HTN diagnosis/billing codes on separate dates in the EHR data AND at least one HTN medication. We calculated an age-standardized HTN prevalence according to the age distribution of the U.S. Census, using 3 groups (18–39, 40–59, and ≥ 60). Among the 185,770 participants enrolled in the AoU Cohort (mean age at enrollment = 51.2 years) available in a Researcher Workbench as of October 2019, EHR data was available for at least one SNOMED code from 112,805 participants, medications for 104,230 participants, and 103,490 participants had both medication and SNOMED data. The total number of persons with SNOMED codes on at least two distinct dates and at least one antihypertensive medication was 33,310 for a crude prevalence of HTN of 32.2%. AoU age-adjusted HTN prevalence was 27.9% using 3 groups compared to 29.6% in NHANES. The AoU cohort is a growing source of diverse longitudinal data to study hypertension nationwide and develop precision rule-based algorithms for use in hypertension treatment and prevention research. The prevalence of hypertension in this cohort is similar to that in prior population-based surveys.
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U2 - 10.1038/s41598-021-92143-w
DO - 10.1038/s41598-021-92143-w
M3 - Article
C2 - 34158555
AN - SCOPUS:85109024727
SN - 2045-2322
VL - 11
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 12849
ER -