Hypertension, preeclampsia and eclampsia among HIV-infected pregnant women from Latin America and Caribbean countries

Elizabeth Stankiewicz Machado, Margot R. Krauss, Karen Megazzini, Conrado Milani Coutinho, Regis Kreitchmann, Victor Hugo Melo, José Henrique Pilotto, Mariana Ceriotto, Cristina B. Hofer, George K. Siberry, D. Heather Watts

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To evaluate the incidence of and risk factors for hypertensive disorders in a cohort of HIV-infected pregnant women. Methods: Hypertensive disorders (HD) including preeclampsia/eclampsia (PE/E) and pregnancy induced hypertension, and risk factors were evaluated in a cohort of HIV-infected pregnant women from Latin America and the Caribbean enrolled between 2002 and 2009. Only pregnant women enrolled for the first time in the study and delivered at ≥20 weeks gestation were analyzed. Results: HD were diagnosed in 73 (4.8%, 95% CI: 3.8%-6.0%) of 1513 patients; 35 (47.9%) had PE/E. HD was significantly increased among women with a gestational age-adjusted body mass index (gBMI) ≥25kg/m2 (OR=3.1; 95% CI: 1.9-5.0), hemoglobin (Hg) ≥11g/dL at delivery (OR=2.1; 95% CI: 1.2-3.6) and age ≥35 years (OR=1.8; 95% CI: 1.1-3.2). PE/E was increased among women with a gBMI ≥25kg/m2 (OR=3.0; 95% CI: 1.5-6.0) and Hg ≥11g/dL at delivery (OR=2.8; 95% CI: 1.2-6.5). A previous history of PE/E increased the risk of PE/E 6.7 fold (95% CI: 1.8-25.5). HAART before conception was associated with PE/E (OR=2.3; 95% CI: 1.1-4.9). Conclusions: HIV-infected women, with a previous history of PE/E, a gBMI ≥25kg/m2, Hg at delivery ≥11g/dL and in use of HAART before conception are at an increased risk of developing PE/E during pregnancy.

Original languageEnglish (US)
Pages (from-to)572-580
Number of pages9
JournalJournal of Infection
Volume68
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Eclampsia
  • HIV-infected women
  • Hypertensive disorders
  • Preeclampsia
  • Pregnancy

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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