Hypertension and smoking are associated with reduced regional left ventricular function in asymptomatic individuals

The Multi-Ethnic Study of Atherosclerosis

Boaz D. Rosen, Mohammed F. Saad, Steven Shea, Khurram Nasir, Thor Edvardsen, Gregory Burke, Michael Jerosch-Herold, Donna K. Arnett, Shenghan Lai, David A. Bluemke, Joao Lima

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: This study sought to test the hypothesis that reduced regional left ventricular (LV) function is associated with traditional risk factors including hypertension, hypercholesterolemia, and smoking in asymptomatic individuals. BACKGROUND: Coronary artery disease is the main etiology of congestive heart failure in the U.S. and Europe. However, the relationship between risk factors for coronary artery disease and decreased myocardial function has not been studied systematically in asymptomatic individuals. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) is a cohort study designed to investigate the nature of atherosclerosis in asymptomatic individuals. A total of 1,184 participants (45 to 84 years old) underwent tagged cardiac magnetic resonance imaging. Regional LV function was quantified by analyzing peak systolic circumferential strain (Ecc) in regions corresponding to the left anterior descending (LAD), circumflex (LCX), and right coronary (RCA) territories. The association between risk factors and strains was studied using multiple linear regression. RESULTS: Higher diastolic blood pressure (DBP) was associated with lower Ecc (p ≤ 0.002). The Ecc's in the LAD territory of participants with DBP

Original languageEnglish (US)
Pages (from-to)1150-1158
Number of pages9
JournalJournal of the American College of Cardiology
Volume47
Issue number6
DOIs
StatePublished - Mar 21 2006

Fingerprint

Left Ventricular Function
Atherosclerosis
Smoking
Blood Pressure
Hypertension
Coronary Artery Disease
Hypercholesterolemia
Linear Models
Cohort Studies
Heart Failure
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Hypertension and smoking are associated with reduced regional left ventricular function in asymptomatic individuals : The Multi-Ethnic Study of Atherosclerosis. / Rosen, Boaz D.; Saad, Mohammed F.; Shea, Steven; Nasir, Khurram; Edvardsen, Thor; Burke, Gregory; Jerosch-Herold, Michael; Arnett, Donna K.; Lai, Shenghan; Bluemke, David A.; Lima, Joao.

In: Journal of the American College of Cardiology, Vol. 47, No. 6, 21.03.2006, p. 1150-1158.

Research output: Contribution to journalArticle

Rosen, Boaz D. ; Saad, Mohammed F. ; Shea, Steven ; Nasir, Khurram ; Edvardsen, Thor ; Burke, Gregory ; Jerosch-Herold, Michael ; Arnett, Donna K. ; Lai, Shenghan ; Bluemke, David A. ; Lima, Joao. / Hypertension and smoking are associated with reduced regional left ventricular function in asymptomatic individuals : The Multi-Ethnic Study of Atherosclerosis. In: Journal of the American College of Cardiology. 2006 ; Vol. 47, No. 6. pp. 1150-1158.
@article{9c71a07766724f77bf6cf4bc88a65ebe,
title = "Hypertension and smoking are associated with reduced regional left ventricular function in asymptomatic individuals: The Multi-Ethnic Study of Atherosclerosis",
abstract = "OBJECTIVES: This study sought to test the hypothesis that reduced regional left ventricular (LV) function is associated with traditional risk factors including hypertension, hypercholesterolemia, and smoking in asymptomatic individuals. BACKGROUND: Coronary artery disease is the main etiology of congestive heart failure in the U.S. and Europe. However, the relationship between risk factors for coronary artery disease and decreased myocardial function has not been studied systematically in asymptomatic individuals. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) is a cohort study designed to investigate the nature of atherosclerosis in asymptomatic individuals. A total of 1,184 participants (45 to 84 years old) underwent tagged cardiac magnetic resonance imaging. Regional LV function was quantified by analyzing peak systolic circumferential strain (Ecc) in regions corresponding to the left anterior descending (LAD), circumflex (LCX), and right coronary (RCA) territories. The association between risk factors and strains was studied using multiple linear regression. RESULTS: Higher diastolic blood pressure (DBP) was associated with lower Ecc (p ≤ 0.002). The Ecc's in the LAD territory of participants with DBP",
author = "Rosen, {Boaz D.} and Saad, {Mohammed F.} and Steven Shea and Khurram Nasir and Thor Edvardsen and Gregory Burke and Michael Jerosch-Herold and Arnett, {Donna K.} and Shenghan Lai and Bluemke, {David A.} and Joao Lima",
year = "2006",
month = "3",
day = "21",
doi = "10.1016/j.jacc.2005.08.078",
language = "English (US)",
volume = "47",
pages = "1150--1158",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Hypertension and smoking are associated with reduced regional left ventricular function in asymptomatic individuals

T2 - The Multi-Ethnic Study of Atherosclerosis

AU - Rosen, Boaz D.

AU - Saad, Mohammed F.

AU - Shea, Steven

AU - Nasir, Khurram

AU - Edvardsen, Thor

AU - Burke, Gregory

AU - Jerosch-Herold, Michael

AU - Arnett, Donna K.

AU - Lai, Shenghan

AU - Bluemke, David A.

AU - Lima, Joao

PY - 2006/3/21

Y1 - 2006/3/21

N2 - OBJECTIVES: This study sought to test the hypothesis that reduced regional left ventricular (LV) function is associated with traditional risk factors including hypertension, hypercholesterolemia, and smoking in asymptomatic individuals. BACKGROUND: Coronary artery disease is the main etiology of congestive heart failure in the U.S. and Europe. However, the relationship between risk factors for coronary artery disease and decreased myocardial function has not been studied systematically in asymptomatic individuals. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) is a cohort study designed to investigate the nature of atherosclerosis in asymptomatic individuals. A total of 1,184 participants (45 to 84 years old) underwent tagged cardiac magnetic resonance imaging. Regional LV function was quantified by analyzing peak systolic circumferential strain (Ecc) in regions corresponding to the left anterior descending (LAD), circumflex (LCX), and right coronary (RCA) territories. The association between risk factors and strains was studied using multiple linear regression. RESULTS: Higher diastolic blood pressure (DBP) was associated with lower Ecc (p ≤ 0.002). The Ecc's in the LAD territory of participants with DBP

AB - OBJECTIVES: This study sought to test the hypothesis that reduced regional left ventricular (LV) function is associated with traditional risk factors including hypertension, hypercholesterolemia, and smoking in asymptomatic individuals. BACKGROUND: Coronary artery disease is the main etiology of congestive heart failure in the U.S. and Europe. However, the relationship between risk factors for coronary artery disease and decreased myocardial function has not been studied systematically in asymptomatic individuals. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) is a cohort study designed to investigate the nature of atherosclerosis in asymptomatic individuals. A total of 1,184 participants (45 to 84 years old) underwent tagged cardiac magnetic resonance imaging. Regional LV function was quantified by analyzing peak systolic circumferential strain (Ecc) in regions corresponding to the left anterior descending (LAD), circumflex (LCX), and right coronary (RCA) territories. The association between risk factors and strains was studied using multiple linear regression. RESULTS: Higher diastolic blood pressure (DBP) was associated with lower Ecc (p ≤ 0.002). The Ecc's in the LAD territory of participants with DBP

UR - http://www.scopus.com/inward/record.url?scp=33644908216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644908216&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2005.08.078

DO - 10.1016/j.jacc.2005.08.078

M3 - Article

VL - 47

SP - 1150

EP - 1158

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 6

ER -