Hypersplenism induced by splenic vein ligation

Brian Garibaldi, Karen E. King, Julie M. Jaffe, Alison R. Moliterno

Research output: Contribution to journalArticlepeer-review


Warm autoimmune hemolytic anemia (AIHA) is a rare clinical entity. It is usually caused by an IgG autoantibody directed against the red blood cell membrane that causes extravascular hemolysis predominantly in the spleen. As a result, disease states or procedures that result in hypersplenism would be expected to increase red cell destruction in patients with an underlying warm AIHA. We present the case of a patient with a previously undiagnosed warm AIHA, who developed worsening hemolysis after undergoing splenic vein ligation during a pancreaticoduodenectomy to remove a neuroendocrine tumor.

Original languageEnglish (US)
Pages (from-to)242-244
Number of pages3
JournalAmerican journal of hematology
Issue number3
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Hematology


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