Hypersensitivity to central serotonin receptor activation in scrapie-infected hamsters and the effect of serotonergic drugs on scrapie symptoms

Jaap Goudsmit, Robert G. Rohwer, Ellen Silbergeld, D. Carleton Gajdusek

Research output: Contribution to journalArticle

Abstract

Low doses of the serotonin agonist, quizapine, and the serotonin precursor, l-5-hydroxytryptophan methyl ester, produce small but significant reductions in scrapie-induced ataxia and action jerks in hamsters. Higher doses of both drugs elicit a behavioral syndrome specific for central serotonin receptor activation. Scrapie-infected hamsters show a dramatic hypersensitivity to both drugs compared to control animals. This suggests that scrapie infection in hamsters causes a disturbance in the serotonergic pathway of the brain stem.

Original languageEnglish (US)
Pages (from-to)372-377
Number of pages6
JournalBrain Research
Volume220
Issue number2
DOIs
StatePublished - Sep 14 1981
Externally publishedYes

Fingerprint

Serotonin Agents
Scrapie
Serotonin Receptors
Cricetinae
Hypersensitivity
5-Hydroxytryptophan
Serotonin Receptor Agonists
Ataxia
Pharmaceutical Preparations
Brain Stem
Serotonin
Esters
Infection

Keywords

  • central serotonin receptors
  • hypersensitivity
  • l-5-hydroxytryptophan methyl ester
  • quipazine
  • scrapie

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Hypersensitivity to central serotonin receptor activation in scrapie-infected hamsters and the effect of serotonergic drugs on scrapie symptoms. / Goudsmit, Jaap; Rohwer, Robert G.; Silbergeld, Ellen; Carleton Gajdusek, D.

In: Brain Research, Vol. 220, No. 2, 14.09.1981, p. 372-377.

Research output: Contribution to journalArticle

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