Hypersensitivity to central serotonin receptor activation in scrapie-infected hamsters and the effect of serotonergic drugs on scrapie symptoms

Jaap Goudsmit, Robert G. Rohwer, Ellen K. Silbergeld, D. Carleton Gajdusek

Research output: Contribution to journalArticlepeer-review

Abstract

Low doses of the serotonin agonist, quizapine, and the serotonin precursor, l-5-hydroxytryptophan methyl ester, produce small but significant reductions in scrapie-induced ataxia and action jerks in hamsters. Higher doses of both drugs elicit a behavioral syndrome specific for central serotonin receptor activation. Scrapie-infected hamsters show a dramatic hypersensitivity to both drugs compared to control animals. This suggests that scrapie infection in hamsters causes a disturbance in the serotonergic pathway of the brain stem.

Original languageEnglish (US)
Pages (from-to)372-377
Number of pages6
JournalBrain research
Volume220
Issue number2
DOIs
StatePublished - Sep 14 1981
Externally publishedYes

Keywords

  • central serotonin receptors
  • hypersensitivity
  • l-5-hydroxytryptophan methyl ester
  • quipazine
  • scrapie

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Hypersensitivity to central serotonin receptor activation in scrapie-infected hamsters and the effect of serotonergic drugs on scrapie symptoms'. Together they form a unique fingerprint.

Cite this