Hyperpolarized 13C MRI of the pulmonary vasculature and parenchyma

Masaru Ishii, Kiarash Emami, Stephen Kadlecek, J. Stefan Petersson, Klaes Golman, Vahid Vahdat, Jiangsheng Yu, Robert V. Cadman, John MacDuffie-Woodburn, Michael Stephen, David A. Lipson, Rahim R. Rizi

Research output: Contribution to journalArticlepeer-review

Abstract

The study of lung perfusion in normal and diseased subjects is of great interest to physiologists and physicians. In this work we demonstrate the application of a liquid-phase hyperpolarized (HP) carbon-13 (13C) tracer to magnetic resonance imaging (MRI) of the pulmonary vasculature and pulmonary perfusion in a porcine model. Our results show that high spatial and temporal resolution images of pulmonary perfusion can be obtained with this contrast technique. Traditionally, pulmonary perfusion measurement techniques have been challenging because of insufficient signal for quantitative functional assessments. The use of polarized 13C in MRI overcomes this limitation and may lead to a viable clinical method for studying the pulmonary vasculature and perfusion.

Original languageEnglish (US)
Pages (from-to)459-463
Number of pages5
JournalMagnetic resonance in medicine
Volume57
Issue number3
DOIs
StatePublished - Mar 2007

Keywords

  • Angiography
  • Functional lung imaging
  • Hyperpolarized carbon-13 MRI
  • Parahydrogen induced polarization
  • Pulmonary perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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