Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo

Peter C.M. van Zijl, Kevin Brindle, Hanzhang Lu, Peter B. Barker, Richard Edden, Nirbhay Yadav, Linda Knutsson

Research output: Contribution to journalReview articlepeer-review

Abstract

Access to metabolic information in vivo using magnetic resonance (MR) technologies has generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI). Metabolic fluxes can be studied using the infusion of substrates labeled with magnetic isotopes, with the use of hyperpolarization especially powerful. Unfortunately, these promising methods are not yet accepted clinically, where fast, simple, and reliable measurement and diagnosis are key. Recent advances in functional MRI and chemical exchange saturation transfer (CEST) MRI allow the use of water imaging to study oxygen metabolism and tissue metabolite levels. These, together with the use of novel data analysis approaches such as machine learning for all of these metabolic MR approaches, are increasing the likelihood of their clinical translation.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalCurrent Opinion in Chemical Biology
Volume63
DOIs
StatePublished - Aug 2021

Keywords

  • CEST
  • CMRO2
  • Deep learning.
  • Hyperpolarization
  • Imaging
  • Metabolism
  • Metabolite
  • Spectroscopy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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