Hyperosmotic arabinose solutions open the tight junctions between brain capillary endothelial cells in tissue culture

Katerina Dorovini-Zis, Phillip D. Bowman, A. Lorris Betz, Gary W. Goldstein

Research output: Contribution to journalArticlepeer-review

Abstract

Tight junctions between bovine brain capillary endothelial cells in primary cell culture are impermeable to horseradish peroxidase (HRP) after 5 min of incubation. However, following 1-5 min of exposure to 1.6 M arabinose, HRP penetrates the extracellular space between successive tight junctions. Endothelial cells in control cultures contain a small number of cytoplasmic pits and vesicles containing HRP which do not increase in number after hyperosmotic treatment.

Original languageEnglish (US)
Pages (from-to)383-386
Number of pages4
JournalBrain research
Volume302
Issue number2
DOIs
StatePublished - Jun 8 1984
Externally publishedYes

Keywords

  • arabinose
  • brain capillary endothelium
  • horseradish peroxidase
  • tight junctions

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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