Hypermethylation pathways to colorectal cancer implications for prevention and detection

James G. Herman

Research output: Contribution to journalArticlepeer-review

Abstract

Epigenetic changes play an important role in the development and progression of colorectal cancer. The best characterized of these changes is the promoter region methylation of CpG islands of genes that play key roles in this disease. These changes compliment and lead to genetic changes that are well established as central to colorectal cancer progression. They may also prove useful in molecular detection approaches.

Original languageEnglish (US)
Pages (from-to)945-958
Number of pages14
JournalGastroenterology Clinics of North America
Volume31
Issue number4
DOIs
StatePublished - Dec 2002

ASJC Scopus subject areas

  • Gastroenterology

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