Hypermethylation of tumor suppressor genes in cancer

James G. Herman

Research output: Contribution to journalArticlepeer-review


Hypermethylation of tumor suppressor genes and other genes functionally important in the neoplastic process is a recently recognised process. This epigenetic process is characterized by loss of function of these genes associated with transcriptional loss in the absence of structural alterations. The growing list of genes inactivated by promoter region hypermethylation provide an opportunity to examine the patterns of inactivation of such genes and provide clues as to the roles these events play in the neoplastic process.

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalSeminars in Cancer Biology
Issue number5
StatePublished - Oct 1999


  • CpG island
  • DNA methylation
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Cancer Research


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