Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma

Z. Jin, Y. Mori, J. Yang, F. Sato, T. Ito, Y. Cheng, B. Paun, James Hamilton, T. Kan, A. Olaru, Stefan David, R. Agarwal, J. M. Abraham, D. Beer, Elizabeth A Montgomery, Stephen Meltzer

Research output: Contribution to journalArticle

Abstract

The nel-like1 (NELL1) gene maps to chromosome 11p15, which frequently undergoes loss of heterozygosity in esophageal adenocarcinoma (EAC). NELL1 promoter hypermethylation was examined by real-time methylation-specific polymerase chain reaction in 259 human esophageal tissues. Hypermethylation of this promoter showed highly discriminative receiver-operator characteristic curve profiles, clearly distinguishing esophageal squamous cell carcinoma (ESCC) and EAC from normal esophagus (NE) (P

Original languageEnglish (US)
Pages (from-to)6332-6340
Number of pages9
JournalOncogene
Volume26
Issue number43
DOIs
StatePublished - Sep 20 2007

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Loss of Heterozygosity
Methylation
Adenocarcinoma
Chromosomes
Polymerase Chain Reaction
Genes
Esophageal Squamous Cell Carcinoma
Adenocarcinoma Of Esophagus

Keywords

  • Biomarker
  • EAC
  • ESCC
  • Hypermethylation
  • NELL1

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma. / Jin, Z.; Mori, Y.; Yang, J.; Sato, F.; Ito, T.; Cheng, Y.; Paun, B.; Hamilton, James; Kan, T.; Olaru, A.; David, Stefan; Agarwal, R.; Abraham, J. M.; Beer, D.; Montgomery, Elizabeth A; Meltzer, Stephen.

In: Oncogene, Vol. 26, No. 43, 20.09.2007, p. 6332-6340.

Research output: Contribution to journalArticle

Jin, Z, Mori, Y, Yang, J, Sato, F, Ito, T, Cheng, Y, Paun, B, Hamilton, J, Kan, T, Olaru, A, David, S, Agarwal, R, Abraham, JM, Beer, D, Montgomery, EA & Meltzer, S 2007, 'Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma', Oncogene, vol. 26, no. 43, pp. 6332-6340. https://doi.org/10.1038/sj.onc.1210461
Jin, Z. ; Mori, Y. ; Yang, J. ; Sato, F. ; Ito, T. ; Cheng, Y. ; Paun, B. ; Hamilton, James ; Kan, T. ; Olaru, A. ; David, Stefan ; Agarwal, R. ; Abraham, J. M. ; Beer, D. ; Montgomery, Elizabeth A ; Meltzer, Stephen. / Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma. In: Oncogene. 2007 ; Vol. 26, No. 43. pp. 6332-6340.
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