TY - JOUR
T1 - Hyperhomocysteinemia predicts renal function decline
T2 - A prospective study in hypertensive adults
AU - Xie, Di
AU - Yuan, Yan
AU - Guo, Jiangnan
AU - Yang, Shenglin
AU - Xu, Xin
AU - Wang, Qin
AU - Li, Youbao
AU - Qin, Xianhui
AU - Tang, Genfu
AU - Huo, Yong
AU - Deng, Guangpu
AU - Wu, Shengjie
AU - Wang, Binyan
AU - Zhang, Qin
AU - Wang, Xiaobin
AU - Fang, Pu
AU - Wang, Hong
AU - Xu, Xiping
AU - Hou, Fanfan
N1 - Funding Information:
This work was supported by the Major State Basic Research Development Program of China (973 program) (No. 2012CB517703), National Key Technologies R&D program (2011BAI10B02) and Major Scientific and Technological Planning Project of Guangzhou City (2010U1-E00821) to Dr. Fan Fan Hou, and a National Nature and Science Grant (No. 81202280) and The PhD Start-up Fund of the Natural Science Foundation of Guangdong Province (S201204006973) to Dr. Di Xie.
PY - 2015/11/10
Y1 - 2015/11/10
N2 - Hyper-homocysteinemia (HHcy) is associated with microalbuminuria and glomerular injury in general and diabetic populations. However, HHcy € s role in hypertensive patients was not studied. We investigated whether HHcy is an independent risk factor for renal function decline and development of chronic kidney disease (CKD) in hypertensive men and women. This was a community-based prospective cohort study of 2,387 hypertensive adults without CKD at baseline, with a mean follow-up of 4.4 years. Baseline and follow-up levels of plasma Hcy, folate, vitamin B12, blood pressure and other pertinent covariables were obtained. CKD was defined as an estimated glomerular filtration rate (EGFR) <60 ml/min/per 1.73 m 2 and an EGFR decline rate >1 ml/min/per 1.73 m 2 /year. There was a graded association between Hcy tertiles and EGFR decline. Subjects in the 3 rd tertile of Hcy levels had an accelerated rate of EGFR decline and an increased risk of incident CKD, as compared with those in the 1st tertile, after adjusting for age, gender, baseline diabetes, SBP, BMI, smoking, dyslipidemia, EGFR, folate and vitamin B12 levels. In conclusion, in this prospective cohort of Chinese hypertensive adults, elevated baseline plasma Hcy can serve as an independent biomarker to predict renal function decline and incident CKD.
AB - Hyper-homocysteinemia (HHcy) is associated with microalbuminuria and glomerular injury in general and diabetic populations. However, HHcy € s role in hypertensive patients was not studied. We investigated whether HHcy is an independent risk factor for renal function decline and development of chronic kidney disease (CKD) in hypertensive men and women. This was a community-based prospective cohort study of 2,387 hypertensive adults without CKD at baseline, with a mean follow-up of 4.4 years. Baseline and follow-up levels of plasma Hcy, folate, vitamin B12, blood pressure and other pertinent covariables were obtained. CKD was defined as an estimated glomerular filtration rate (EGFR) <60 ml/min/per 1.73 m 2 and an EGFR decline rate >1 ml/min/per 1.73 m 2 /year. There was a graded association between Hcy tertiles and EGFR decline. Subjects in the 3 rd tertile of Hcy levels had an accelerated rate of EGFR decline and an increased risk of incident CKD, as compared with those in the 1st tertile, after adjusting for age, gender, baseline diabetes, SBP, BMI, smoking, dyslipidemia, EGFR, folate and vitamin B12 levels. In conclusion, in this prospective cohort of Chinese hypertensive adults, elevated baseline plasma Hcy can serve as an independent biomarker to predict renal function decline and incident CKD.
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U2 - 10.1038/srep16268
DO - 10.1038/srep16268
M3 - Article
C2 - 26553372
AN - SCOPUS:84947288762
SN - 2045-2322
VL - 5
JO - Scientific reports
JF - Scientific reports
M1 - 16268
ER -