Hyperglycemic ischemia of rat brain: the effect of post-ischemic insulin on metabolic rate

E. Siemkowicz, A. J. Hansen, A. Gjedde

Research output: Contribution to journalArticlepeer-review

Abstract

To identify the mechanism by which hyperglycemia impairs recovery after cerebral ischemia, cortical blood flow (CBF), cortical metabolic rate for oxygen (CMRO2), and the cortical phosphorylation rate for glucose (CPRglc) were measured in rats 1 h after a global ischemic insult of the brain. A control group remained hyperglycemic after ischemia. The experimental group received insulin which reduced plasma glucose during the period of recirculation after ischemia. Thus, the brains of both groups were hyperglycemic before and during ischemia. The CMRO2 after ischemia was higher in insulin-treated rats than in hyperglycemic rats (250 vs 168 μmol·100 g-1·min-1) while the CPRglc was lower (22 vs 58 μmol·100 g-1·min-1). We conclude that glucose-induced inhibition of oxygen consumption in brain contributes to the impaired recovery after ischemia.

Original languageEnglish (US)
Pages (from-to)386-390
Number of pages5
JournalBrain research
Volume243
Issue number2
DOIs
StatePublished - Jul 15 1982

Keywords

  • brain metabolism
  • hyperglycemic ischemia
  • insulin
  • metabolic rate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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