Hyperglycemia-induced small intestinal dysrhythmias attributed to sympathovagal imbalance in normal and diabetic rats

X. Ouyang, Shiying Li, R. Foreman, J. Farber, L. Lin, Jieyun Yin, Jiande Chen

Research output: Contribution to journalArticle

Abstract

Background: Hyperglycemia is known to induce dysrhythmias in the stomach; however, it is unknown whether they are also induced in the small intestine. Autonomic dysfunction is commonly noted in diabetes but the role it plays in hyperglycemia-induced dysrhythmias remains unknown. This study aimed to explore the effects of hyperglycemia on intestinal myoelectrical activity and the role of autonomic functions in hyperglycemia. Methods: Small intestinal myoelectrical activity (slow wave and spike activity) and autonomic functions (assessed by the spectral analysis of heart rate variability) were measured in Goto-Kakizaki diabetic rats and control rats treated with acute glucagon. Blood glucose was measured and its correlation with intestinal slow waves was determined. Key Results: (1) The diabetic rats showed reduced regularity in intestinal slow waves in fasting and fed states (p <0.001 for both), and increased sympathovagal balance (p <0.05) in comparison with the control rats. The regularity in intestinal slow waves was negatively correlated with the HbA1c level in all rats (r = -0.663, p = 0.000). (2) Glucagon injection in the control rats induced transient hyperglycemia, intestinal slow wave dysrhythmias and impaired autonomic functions, similar to those observed in the diabetic rats. The increase in blood glucose was correlated with the decrease in the regularity of intestinal slow waves (r = -0.739, p = 0.015). Conclusions & Inferences: Both spontaneous and glucagon-induced hyperglycemia results in slow wave dysrhythmias in the small intestine. Impairment in autonomic functions (increased sympathovagal balance) may play a role in hyperglycemia-induced dysrhythmias. This study suggests that hyperglycemia results in slow wave dysrhythmias in the small intestine. Impairment in autonomic functions is believed to play a role in hyperglycemia-induced slow wave dysrhythmias.

Original languageEnglish (US)
Pages (from-to)406-415
Number of pages10
JournalNeurogastroenterology and Motility
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2015

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Hyperglycemia
Glucagon
Small Intestine
Blood Glucose
Fasting
Stomach
Heart Rate
Injections

Keywords

  • Autonomic function
  • Diabetes
  • Gastrointestinal motility
  • Hyperglycemia
  • Small intestinal slow wave

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology
  • Medicine(all)

Cite this

Hyperglycemia-induced small intestinal dysrhythmias attributed to sympathovagal imbalance in normal and diabetic rats. / Ouyang, X.; Li, Shiying; Foreman, R.; Farber, J.; Lin, L.; Yin, Jieyun; Chen, Jiande.

In: Neurogastroenterology and Motility, Vol. 27, No. 3, 01.03.2015, p. 406-415.

Research output: Contribution to journalArticle

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abstract = "Background: Hyperglycemia is known to induce dysrhythmias in the stomach; however, it is unknown whether they are also induced in the small intestine. Autonomic dysfunction is commonly noted in diabetes but the role it plays in hyperglycemia-induced dysrhythmias remains unknown. This study aimed to explore the effects of hyperglycemia on intestinal myoelectrical activity and the role of autonomic functions in hyperglycemia. Methods: Small intestinal myoelectrical activity (slow wave and spike activity) and autonomic functions (assessed by the spectral analysis of heart rate variability) were measured in Goto-Kakizaki diabetic rats and control rats treated with acute glucagon. Blood glucose was measured and its correlation with intestinal slow waves was determined. Key Results: (1) The diabetic rats showed reduced regularity in intestinal slow waves in fasting and fed states (p <0.001 for both), and increased sympathovagal balance (p <0.05) in comparison with the control rats. The regularity in intestinal slow waves was negatively correlated with the HbA1c level in all rats (r = -0.663, p = 0.000). (2) Glucagon injection in the control rats induced transient hyperglycemia, intestinal slow wave dysrhythmias and impaired autonomic functions, similar to those observed in the diabetic rats. The increase in blood glucose was correlated with the decrease in the regularity of intestinal slow waves (r = -0.739, p = 0.015). Conclusions & Inferences: Both spontaneous and glucagon-induced hyperglycemia results in slow wave dysrhythmias in the small intestine. Impairment in autonomic functions (increased sympathovagal balance) may play a role in hyperglycemia-induced dysrhythmias. This study suggests that hyperglycemia results in slow wave dysrhythmias in the small intestine. Impairment in autonomic functions is believed to play a role in hyperglycemia-induced slow wave dysrhythmias.",
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AU - Yin, Jieyun

AU - Chen, Jiande

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KW - Gastrointestinal motility

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