Hyperglycemia after pediatric cardiac surgery: Impact of age and residual lesions

Michael Alice Moga, Cedric Manlhiot, Eva M. Marwali, Brian W. McCrindle, Glen S. Van Arsdell, Steven M. Schwartz

Research output: Contribution to journalArticle

Abstract

Objective: We evaluated the effect of patient age and significant residual cardiac lesions on the association between hyperglycemia and adverse outcomes in children after cardiac surgery. The incidence, severity, and duration of hyperglycemia in this patient population and perioperative factors predisposing to hyperglycemia were also delineated. Design: Retrospective, observational cohort study. Setting: Eighteen-bed pediatric cardiac critical care unit. Patients: Seven hundred seventy-two children undergoing cardiac surgery with cardiopulmonary bypass during 2006 and 2007. Interventions: None. Measurements and Main Results: Postoperative glucose levels were reviewed in all children who underwent cardiac surgery with cardiopulmonary bypass at our institution during 2006 and 2007 who met all inclusion criteria and none of the exclusion criteria (n = 772). The composite morbidity-mortality outcome included hospital death, cardiac arrest, renal/hepatic failure, lactic acidosis, extracorporeal membrane oxygenation use, or infection. Hyperglycemia occurred in 90% of patients and resolved within 72 hrs in most without exogenous insulin. Preoperative factors, including prostaglandins, mechanical ventilation, and cyanosis, were significantly associated with increased odds of significant hyperglycemia (>180 mg/dL for >12 hrs or any level >270 mg/dL) as were increased surgical complexity and perioperative steroid administration. Thirty-one percent of the entire cohort reached the composite outcome and the odds were significantly increased after 54 hrs of mild (elevated, but <180 mg/dL), 12 hrs of moderate (180-270 mg/dL), or any period of severe hyperglycemia (>270 mg/dL). Neonates (<1 month of age) tolerated longer periods of hyperglycemia before showing increased odds of reaching the composite morbidity-mortality end point. In the setting of important residual cardiac lesions, mild or moderate hyperglycemia was not as strongly associated with adverse outcomes. Conclusions: Age and residual cardiac lesions are important modifiers of the association between hyperglycemia and suboptimal outcomes after pediatric cardiac surgery. Use of insulin therapy for glucose control in this patient population may need to be carefully targeted toward high-risk subsets of patients.

Original languageEnglish (US)
Pages (from-to)266-272
Number of pages7
JournalCritical care medicine
Volume39
Issue number2
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

Hyperglycemia
Thoracic Surgery
Pediatrics
Cardiopulmonary Bypass
Insulin
Morbidity
Glucose
Lactic Acidosis
Extracorporeal Membrane Oxygenation
Cyanosis
Mortality
Liver Failure
Critical Care
Heart Arrest
Artificial Respiration
Causality
Population
Prostaglandins
Observational Studies
Renal Insufficiency

Keywords

  • cardiovascular surgery
  • hyperglycemia
  • intensive care
  • pediatrics

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Moga, M. A., Manlhiot, C., Marwali, E. M., McCrindle, B. W., Van Arsdell, G. S., & Schwartz, S. M. (2011). Hyperglycemia after pediatric cardiac surgery: Impact of age and residual lesions. Critical care medicine, 39(2), 266-272. https://doi.org/10.1097/CCM.0b013e3181fee88e

Hyperglycemia after pediatric cardiac surgery : Impact of age and residual lesions. / Moga, Michael Alice; Manlhiot, Cedric; Marwali, Eva M.; McCrindle, Brian W.; Van Arsdell, Glen S.; Schwartz, Steven M.

In: Critical care medicine, Vol. 39, No. 2, 01.01.2011, p. 266-272.

Research output: Contribution to journalArticle

Moga, MA, Manlhiot, C, Marwali, EM, McCrindle, BW, Van Arsdell, GS & Schwartz, SM 2011, 'Hyperglycemia after pediatric cardiac surgery: Impact of age and residual lesions', Critical care medicine, vol. 39, no. 2, pp. 266-272. https://doi.org/10.1097/CCM.0b013e3181fee88e
Moga, Michael Alice ; Manlhiot, Cedric ; Marwali, Eva M. ; McCrindle, Brian W. ; Van Arsdell, Glen S. ; Schwartz, Steven M. / Hyperglycemia after pediatric cardiac surgery : Impact of age and residual lesions. In: Critical care medicine. 2011 ; Vol. 39, No. 2. pp. 266-272.
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