Hypereosinophilia presenting as eosinophilic vasculitis and multiple peripheral artery occlusions without organ involvement

Sung Hwan Kim, Tae Bum Kim, Young Sun Yun, Jung Im Shin, Il Young Oh, Jung Ju Sir, Kyung Mook Kim, Hye Kyung Park, Hye Ryun Kang, Yoon Seok Chang, Yoon Keun Kim, Sang Heon Cho, Yeong Wook Song, Dong Chul Choi, Kyung Up Min, You Young Kim

Research output: Contribution to journalArticle


We report here a case with hypereosinophilia and peripheral artery occlusion. A 32-yr-old Korean woman presented to us with lower extremity swelling and pain. Angiography revealed that multiple lower extremity arteries were occlusive. The biopsy specimen showed perivascular and periadnexal dense eosinophilic infiltration in dermis and subcutaneous adipose tissue. Laboratory investigations revealed a persistent hypereosinophilia. She was prescribed prednisolone 60 mg daily. Her skin lesion and pain were improved and the eosinophil count was dramatically decreased. After discharge, eosinophil count gradually increased again. Cyanosis and pain of her fingers recurred. She had been treated with cyclophosphamide pulse therapy. Her eosinophilia was decreased, but the cyanosis and tingling sense were progressive. The extremity arterial stenoses were slightly progressed. Skin biopsy showed perivascular eosinophilic infiltration in the dermis and CD40 ligand (CD40L) positive eosinophilic infiltration. The serum TNF-α was markedly increased. These results suggest that CD40L (a member of TNF-α superfamily) could play a role in the inflammatory processes when eosinophil infiltration and activation are observed. We prescribed prednisolone, cyclophosphamide, clopidogrel, cilostazol, beraprost and nifedipine, and she was discharged.

Original languageEnglish (US)
Pages (from-to)677-679
Number of pages3
JournalJournal of Korean Medical Science
Issue number4
StatePublished - Aug 2005


  • CD40 Ligand
  • Hypereosinophilic Syndrome
  • Tumor Necrosis Factor-alpha
  • Vasculitis

ASJC Scopus subject areas

  • Medicine(all)

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