Abstract
Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE2 (PGE2).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.
Original language | English (US) |
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Pages (from-to) | 357-362 |
Number of pages | 6 |
Journal | Japanese Journal of Clinical Oncology |
Volume | 17 |
Issue number | 4 |
State | Published - Dec 1 1987 |
Externally published | Yes |
Keywords
- Common acute lymphoblastic leukemia
- Hypercalcemia
- Prostaglandin E2
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research