Hypercalcemia in a case of childhood acute lymphoblastic leukemia

Shinjiro Todo; Shinsaku Imashuku; Hiroshi Inoda; Hirofumi Yamanaka; Shigeyoshi Hibi; Kentaro Tsunamoto; Noriko Esumi; Fumihiro Fujiwara; Yoshitaka Shimizu; Yoshihito Morioka; Tohru Sugimoto

Hypercalcemia in a case of childhood acute lymphoblastic leukemia

Shinjiro Todo, Shinsaku Imashuku, Hiroshi Inoda, Hirofumi Yamanaka, Shigeyoshi Hibi, Kentaro Tsunamoto, Noriko Esumi, Fumihiro Fujiwara, Yoshitaka Shimizu, Yoshihito Morioka, Tohru Sugimoto

Research output: Contribution to journal › Article

Abstract

Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE₂ (PGE₂).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE₂ level returned to normal after chemotherapy.

Original language	English (US)
Pages (from-to)	357-362
Number of pages	6
Journal	Japanese Journal of Clinical Oncology
Volume	17
Issue number	4
State	Published - Dec 1 1987
Externally published	Yes

Keywords

Common acute lymphoblastic leukemia
Hypercalcemia
Prostaglandin E2

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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Todo, S., Imashuku, S., Inoda, H., Yamanaka, H., Hibi, S., Tsunamoto, K., Esumi, N., Fujiwara, F., Shimizu, Y., Morioka, Y., & Sugimoto, T. (1987). Hypercalcemia in a case of childhood acute lymphoblastic leukemia. Japanese Journal of Clinical Oncology, 17(4), 357-362.

Hypercalcemia in a case of childhood acute lymphoblastic leukemia. / Todo, Shinjiro; Imashuku, Shinsaku; Inoda, Hiroshi; Yamanaka, Hirofumi; Hibi, Shigeyoshi; Tsunamoto, Kentaro; Esumi, Noriko; Fujiwara, Fumihiro; Shimizu, Yoshitaka; Morioka, Yoshihito; Sugimoto, Tohru.

In: Japanese Journal of Clinical Oncology, Vol. 17, No. 4, 01.12.1987, p. 357-362.

Research output: Contribution to journal › Article

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AU - Tsunamoto, Kentaro

AU - Esumi, Noriko

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AB - Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE2 (PGE2).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.

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