Hypercalcemia in a case of childhood acute lymphoblastic leukemia

Shinjiro Todo; Shinsaku Imashuku; Hiroshi Inoda; Hirofumi Yamanaka; Shigeyoshi Hibi; Kentaro Tsunamoto; Noriko Esumi; Fumihiro Fujiwara; Yoshitaka Shimizu; Yoshihito Morioka; Tohru Sugimoto

Hypercalcemia in a case of childhood acute lymphoblastic leukemia

Shinjiro Todo, Shinsaku Imashuku, Hiroshi Inoda, Hirofumi Yamanaka, Shigeyoshi Hibi, Kentaro Tsunamoto, Noriko Esumi, Fumihiro Fujiwara, Yoshitaka Shimizu, Yoshihito Morioka, Tohru Sugimoto

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE₂ (PGE₂).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE₂ level returned to normal after chemotherapy.

Original language	English (US)
Pages (from-to)	357-362
Number of pages	6
Journal	Japanese Journal of Clinical Oncology
Volume	17
Issue number	4
State	Published - Dec 1 1987
Externally published	Yes

Keywords

Common acute lymphoblastic leukemia
Hypercalcemia
Prostaglandin E2

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

Cite this

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title = "Hypercalcemia in a case of childhood acute lymphoblastic leukemia",

abstract = "Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE2 (PGE2).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.",

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T1 - Hypercalcemia in a case of childhood acute lymphoblastic leukemia

AU - Todo, Shinjiro

AU - Imashuku, Shinsaku

AU - Inoda, Hiroshi

AU - Yamanaka, Hirofumi

AU - Hibi, Shigeyoshi

AU - Tsunamoto, Kentaro

AU - Esumi, Noriko

AU - Fujiwara, Fumihiro

AU - Shimizu, Yoshitaka

AU - Morioka, Yoshihito

AU - Sugimoto, Tohru

PY - 1987/12/1

Y1 - 1987/12/1

N2 - Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE2 (PGE2).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.

AB - Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE2 (PGE2).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.

KW - Common acute lymphoblastic leukemia

KW - Hypercalcemia

KW - Prostaglandin E2

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Hypercalcemia in a case of childhood acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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