Abstract
Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandin E2 (PGE2) levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 357-362 |
| Number of pages | 6 |
| Journal | Japanese Journal of Clinical Oncology |
| Volume | 17 |
| Issue number | 4 |
| State | Published - Dec 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Radiology Nuclear Medicine and imaging
- Cancer Research
Cite this
Hypercalcemia in a case of childhood acute lymphoblastic leukemia. / Todo, S.; Imashuku, S.; Inoda, H.; Yamanaka, H.; Hibi, S.; Tsunamoto, K.; Esumi, Noriko; Fujiwara, F.; Shimizu, Y.; Morioka, Y.
In: Japanese Journal of Clinical Oncology, Vol. 17, No. 4, 12.1987, p. 357-362.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypercalcemia in a case of childhood acute lymphoblastic leukemia.
AU - Todo, S.
AU - Imashuku, S.
AU - Inoda, H.
AU - Yamanaka, H.
AU - Hibi, S.
AU - Tsunamoto, K.
AU - Esumi, Noriko
AU - Fujiwara, F.
AU - Shimizu, Y.
AU - Morioka, Y.
PY - 1987/12
Y1 - 1987/12
N2 - Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandin E2 (PGE2) levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.
AB - Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandin E2 (PGE2) levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=0023508049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023508049&partnerID=8YFLogxK
M3 - Article
C2 - 3320403
AN - SCOPUS:0023508049
VL - 17
SP - 357
EP - 362
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 4
ER -