Hypercalcemia in a case of childhood acute lymphoblastic leukemia.

S. Todo, S. Imashuku, H. Inoda, H. Yamanaka, S. Hibi, K. Tsunamoto, Noriko Esumi, F. Fujiwara, Y. Shimizu, Y. Morioka

Research output: Contribution to journalArticle

Abstract

Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandin E2 (PGE2) levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume17
Issue number4
StatePublished - Dec 1987
Externally publishedYes

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Prostaglandins
Leukemia
Hypercalcemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute
Plasma
Plasmas
Chemotherapy
Secretion
Hormones
Calcium
Dinoprostone
Bone
Ectopic Hormones
Primary Hyperparathyroidism
Cell
Parathyroid Hormone
Bone and Bones
Drug Therapy
Childhood

ASJC Scopus subject areas

  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Todo, S., Imashuku, S., Inoda, H., Yamanaka, H., Hibi, S., Tsunamoto, K., ... Morioka, Y. (1987). Hypercalcemia in a case of childhood acute lymphoblastic leukemia. Japanese Journal of Clinical Oncology, 17(4), 357-362.

Hypercalcemia in a case of childhood acute lymphoblastic leukemia. / Todo, S.; Imashuku, S.; Inoda, H.; Yamanaka, H.; Hibi, S.; Tsunamoto, K.; Esumi, Noriko; Fujiwara, F.; Shimizu, Y.; Morioka, Y.

In: Japanese Journal of Clinical Oncology, Vol. 17, No. 4, 12.1987, p. 357-362.

Research output: Contribution to journalArticle

Todo, S, Imashuku, S, Inoda, H, Yamanaka, H, Hibi, S, Tsunamoto, K, Esumi, N, Fujiwara, F, Shimizu, Y & Morioka, Y 1987, 'Hypercalcemia in a case of childhood acute lymphoblastic leukemia.', Japanese Journal of Clinical Oncology, vol. 17, no. 4, pp. 357-362.
Todo S, Imashuku S, Inoda H, Yamanaka H, Hibi S, Tsunamoto K et al. Hypercalcemia in a case of childhood acute lymphoblastic leukemia. Japanese Journal of Clinical Oncology. 1987 Dec;17(4):357-362.
Todo, S. ; Imashuku, S. ; Inoda, H. ; Yamanaka, H. ; Hibi, S. ; Tsunamoto, K. ; Esumi, Noriko ; Fujiwara, F. ; Shimizu, Y. ; Morioka, Y. / Hypercalcemia in a case of childhood acute lymphoblastic leukemia. In: Japanese Journal of Clinical Oncology. 1987 ; Vol. 17, No. 4. pp. 357-362.
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