Hypercalcemia in a case of childhood acute lymphoblastic leukemia

Shinjiro Todo, Shinsaku Imashuku, Hiroshi Inoda, Hirofumi Yamanaka, Shigeyoshi Hibi, Kentaro Tsunamoto, Noriko Esumi, Fumihiro Fujiwara, Yoshitaka Shimizu, Yoshihito Morioka, Tohru Sugimoto

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Severe hypercalcemia (serum calcium, 4.25-5.25 mmol/l), in association with osteolytic bone lesions, was found in a girl aged 2 yr 7 mo with common acute lymphoblastic leukemia (ALL). Hormonal studies excluded the possibility of the hypercalcemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Increased plasma prostaglandinE2 (PGE2).J levels (130 ng/l), probably produced by leukemic cells, were considered to be one of the pathogenic mechanisms responsible for the occurrence of hypercalcemia in this patient. Both the hypercalcemia and the abnormal plasma PGE2 level returned to normal after chemotherapy.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalJapanese Journal of Clinical Oncology
Issue number4
StatePublished - Dec 1 1987
Externally publishedYes


  • Common acute lymphoblastic leukemia
  • Hypercalcemia
  • Prostaglandin E2

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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