Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: Report of two new cases and subject review

Susanna L. Matsen, Charles J. Yeo, Ralph H Hruban, Michael A. Choti

Research output: Contribution to journalArticle

Abstract

Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.

Original languageEnglish (US)
Pages (from-to)270-279
Number of pages10
JournalJournal of Gastrointestinal Surgery
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2005

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Parathyroid Hormone-Related Protein
Hypercalcemia
Exocrine Pancreas
Neoplasms
Peptides
Type C Phospholipases
Pancreatic Neoplasms
Adenylyl Cyclases
Calcium
Kidney

Keywords

  • Hypercalcemia
  • Pancreatic endocrine neoplasm
  • PTH-rP

ASJC Scopus subject areas

  • Surgery

Cite this

Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP : Report of two new cases and subject review. / Matsen, Susanna L.; Yeo, Charles J.; Hruban, Ralph H; Choti, Michael A.

In: Journal of Gastrointestinal Surgery, Vol. 9, No. 2, 01.02.2005, p. 270-279.

Research output: Contribution to journalArticle

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