Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: Report of two new cases and subject review

Susanna L. Matsen; Charles J. Yeo; Ralph H. Hruban; Michael A. Choti

doi:10.1016/j.gassur.2004.06.012

Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: Report of two new cases and subject review

Susanna L. Matsen, Charles J. Yeo, Ralph H. Hruban, Michael A. Choti

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.

Original language	English (US)
Pages (from-to)	270-279
Number of pages	10
Journal	Journal of Gastrointestinal Surgery
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/j.gassur.2004.06.012
State	Published - Feb 1 2005

Keywords

Hypercalcemia
PTH-rP
Pancreatic endocrine neoplasm

ASJC Scopus subject areas

Surgery
Gastroenterology

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10.1016/j.gassur.2004.06.012

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abstract = "Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.",

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AU - Choti, Michael A.

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AB - Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.

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KW - Pancreatic endocrine neoplasm

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Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: Report of two new cases and subject review

Abstract

Keywords

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