TY - JOUR
T1 - Hyperapobetalipoproteinemia
T2 - the major dyslipoproteinemia in patients with chronic renal failure treated with chronic ambulatory peritoneal dialysis
AU - Sniderman, Allan
AU - Cianflone, Katherine
AU - Kwiterovich, Peter O.
AU - Hutchinson, Tom
AU - Barre, Paul
AU - Prichard, Sarah
N1 - Funding Information:
This work was supported by a grant from the Kidney Foundation of Canada.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1987/6
Y1 - 1987/6
N2 - In the present study, plasma cholesterol, triglyceride, low density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)-cholesterol, and the major protein in LDL, apoB, were measured in 28 patients with chronic renal failure treated with hemodialysis and in 28 patients with chronic renal failure treated with chronic ambulatory peritoneal dialysis (CAPD). Elevated plasma triglycerides and reduced HDL cholesterol were frequent in both the hemodialysis and CAPD patients. However LDL levels were significantly higher in the CAPD patients as evident both by LDL cholesterol and LDL apoB. Even so, only one of the CAPD patients was hypercholesterolemic whereas 14 (or 50%) had hyperapobetalipoproteinemia (Hyper apoB). Insulin-dependent diabetes was more frequent in the CAPD group but only 2 of the 9 insulin-dependent diabetics in this group had HyperapoB, and therefore, diabetes mellitus cannot account for the difference between the 2 groups. Thus HyperapoB appears to be a prevalent dyslipoproteinemia in CAPD patients and as such might be another factor which places CAPD patients at particularly increased risk of atherosclerosis.
AB - In the present study, plasma cholesterol, triglyceride, low density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)-cholesterol, and the major protein in LDL, apoB, were measured in 28 patients with chronic renal failure treated with hemodialysis and in 28 patients with chronic renal failure treated with chronic ambulatory peritoneal dialysis (CAPD). Elevated plasma triglycerides and reduced HDL cholesterol were frequent in both the hemodialysis and CAPD patients. However LDL levels were significantly higher in the CAPD patients as evident both by LDL cholesterol and LDL apoB. Even so, only one of the CAPD patients was hypercholesterolemic whereas 14 (or 50%) had hyperapobetalipoproteinemia (Hyper apoB). Insulin-dependent diabetes was more frequent in the CAPD group but only 2 of the 9 insulin-dependent diabetics in this group had HyperapoB, and therefore, diabetes mellitus cannot account for the difference between the 2 groups. Thus HyperapoB appears to be a prevalent dyslipoproteinemia in CAPD patients and as such might be another factor which places CAPD patients at particularly increased risk of atherosclerosis.
KW - Chronic ambulatory peritoneal dialysis
KW - Chronic renal failure
KW - Dyslipoproteinemia
KW - Hemodialysis
KW - Hyperapobetalipoproteinemia
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U2 - 10.1016/0021-9150(87)90041-4
DO - 10.1016/0021-9150(87)90041-4
M3 - Article
C2 - 3619989
AN - SCOPUS:0023186916
SN - 0021-9150
VL - 65
SP - 257
EP - 264
JO - Atherosclerosis
JF - Atherosclerosis
IS - 3
ER -