Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease

a case report and review of the literature

Uzoma A. Anele, A. Kyle Mack, Linda M Smith Resar, Arthur Burnett

Research output: Contribution to journalArticle

Abstract

Prolonged ischemic priapism in patients with sickling hemoglobinopathies is a urologic emergency requiring immediate intervention to avoid irreversible anoxic penile injury, corporal fibrosis, and erectile dysfunction. Therapeutic options, however, are limited and often ineffective. Here, we report recovery of erectile function with hydroxyurea therapy in an adolescent with hemoglobin SS following a prolonged episode of priapism and subsequent severe erectile dysfunction. This case suggests a potential role of hydroxyurea in reversing end organ damage in patients with hemoglobin SS and also supports basic science work indicating involvement of the NO-dependent pathway in the pathogenesis of sickle cell disease-associated priapism.

Original languageEnglish (US)
Pages (from-to)1733-1736
Number of pages4
JournalInternational Urology and Nephrology
Volume46
Issue number9
DOIs
StatePublished - Sep 1 2014

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Priapism
Hydroxyurea
Recovery of Function
Sickle Cell Anemia
Sickle Hemoglobin
Erectile Dysfunction
Hemoglobinopathies
Emergencies
Fibrosis
Therapeutics
Wounds and Injuries

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

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