ABSTRACT: Hydroxychloroquine is the cornerstone of medical therapy in systemic lupus erythematosus (SLE). We report a case of erythema multiforme in association with this medication in a 25-year-old white woman with SLE. We provide a detailed review of the reported cases in the literature of hydroxychloroquine-induced severe cutaneous adverse reactions. To our knowledge, this is the first reported case of hydroxychloroquine-induced erythema multiforme in the setting of SLE.
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