Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease

Research output: Contribution to journalArticle

Abstract

A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine.

Original languageEnglish (US)
Pages (from-to)306-309
Number of pages4
JournalAmerican Journal of Hematology
Volume78
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Hydroxychloroquine
Graft vs Host Disease
Muscular Diseases
Mantle-Cell Lymphoma
Respiratory Muscles
Polyneuropathies
Muscle Weakness
Electromyography
Cholinergic Receptors
Creatine Kinase
Vacuoles
Extremities
Bone Marrow
Transplants
Biopsy
Muscles
Antibodies
Serum
Pharmaceutical Preparations
Vacuolar myopathy

Keywords

  • Graft-versus-host disease
  • Hydroxychloroquine
  • Myopathy
  • Vacuolar myopathy

ASJC Scopus subject areas

  • Hematology

Cite this

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title = "Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease",
abstract = "A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine.",
keywords = "Graft-versus-host disease, Hydroxychloroquine, Myopathy, Vacuolar myopathy",
author = "{Bolanos Meade}, {F Javier} and Lan Zhou and Ahmet Hoke and Corse, {Andrea Markl} and Vogelsang, {Georgia Boyce} and Wagner, {Kathryn Rae}",
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AU - Bolanos Meade, F Javier

AU - Zhou, Lan

AU - Hoke, Ahmet

AU - Corse, Andrea Markl

AU - Vogelsang, Georgia Boyce

AU - Wagner, Kathryn Rae

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AB - A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine.

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