Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase

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Abstract

Background:Hydroquinone is a benzene metabolite shown to lead to decreased DNA methylation. Results:Hydroquinone exposure increases Ten Eleven Translocation 1 methylcytosine dioxygenase activity and 5-hydroxymethylcytosine levels and decreases DNA methylation. Conclusion:Hydroquinone leads to DNA demethylation through a Ten Eleven Translocation 1-dependent mechanism. Significance:This mechanism may explain observations of decreased DNA methylation and cytotoxicity following exposure to benzene and hydroquinone.

Original languageEnglish (US)
Pages (from-to)28792-28800
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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