Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding

Waka Nakanishi, Kazuya Kikuchi, Takanari Inoue, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano

Research output: Contribution to journalArticlepeer-review

Abstract

Inositol 1,4,5-trisphosphate (IP3) analogues were synthesized in order to investigate the importance of the environment of 1-phosphate of IP3 for strong binding to the IP3 receptor. Our results show that hydrophobic modifications of the 1-phosphate moiety enhance the binding affinity, with considerable latitude of substituent structure.

Original languageEnglish (US)
Pages (from-to)911-913
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number6
DOIs
StatePublished - Mar 25 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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