Hydromorphone effects on human conversational speech

Maxine L. Stitzer, Mary E. McCaul, George E. Bigleow, Ira A. Liebson

Research output: Contribution to journalArticle

Abstract

The present study provides an objective assessment of the increased talkativeness associated with acute opiate drug administration. Speech of five methadone-maintenance subjects was recorded continuously for 1 h following the injection of 0, 10, 14, or 18 mg hydromorphone. Dose-related increases in subjects' speech were observed, while no systematic changes were seen in speech of an undrugged partner. Dose-related increases were also obtained on an adjective checklist measuring characteristic opiate signs and symptoms. The relationship between behavioral, subjective, and reinforcing drug effects is discussed.

Original languageEnglish (US)
Pages (from-to)402-404
Number of pages3
JournalPsychopharmacology
Volume84
Issue number3
DOIs
StatePublished - Sep 1 1984

Keywords

  • Behavioral effects
  • Drug abusers
  • Drug reinforcement
  • Human speech
  • Hydromorphone
  • Opiate drugs
  • Subjective effects

ASJC Scopus subject areas

  • Pharmacology

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