Hydromorphone effects on human conversational speech

Maxine L. Stitzer; Mary E. McCaul; George E. Bigleow; Ira A. Liebson

doi:10.1007/BF00555221

Hydromorphone effects on human conversational speech

Maxine L. Stitzer, Mary E. McCaul, George E. Bigleow, Ira A. Liebson

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The present study provides an objective assessment of the increased talkativeness associated with acute opiate drug administration. Speech of five methadone-maintenance subjects was recorded continuously for 1 h following the injection of 0, 10, 14, or 18 mg hydromorphone. Dose-related increases in subjects' speech were observed, while no systematic changes were seen in speech of an undrugged partner. Dose-related increases were also obtained on an adjective checklist measuring characteristic opiate signs and symptoms. The relationship between behavioral, subjective, and reinforcing drug effects is discussed.

Original language	English (US)
Pages (from-to)	402-404
Number of pages	3
Journal	Psychopharmacology
Volume	84
Issue number	3
DOIs	https://doi.org/10.1007/BF00555221
State	Published - Sep 1 1984

Keywords

Behavioral effects
Drug abusers
Drug reinforcement
Human speech
Hydromorphone
Opiate drugs
Subjective effects

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00555221

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title = "Hydromorphone effects on human conversational speech",

abstract = "The present study provides an objective assessment of the increased talkativeness associated with acute opiate drug administration. Speech of five methadone-maintenance subjects was recorded continuously for 1 h following the injection of 0, 10, 14, or 18 mg hydromorphone. Dose-related increases in subjects' speech were observed, while no systematic changes were seen in speech of an undrugged partner. Dose-related increases were also obtained on an adjective checklist measuring characteristic opiate signs and symptoms. The relationship between behavioral, subjective, and reinforcing drug effects is discussed.",

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AU - Stitzer, Maxine L.

AU - McCaul, Mary E.

AU - Bigleow, George E.

AU - Liebson, Ira A.

PY - 1984/9/1

Y1 - 1984/9/1

N2 - The present study provides an objective assessment of the increased talkativeness associated with acute opiate drug administration. Speech of five methadone-maintenance subjects was recorded continuously for 1 h following the injection of 0, 10, 14, or 18 mg hydromorphone. Dose-related increases in subjects' speech were observed, while no systematic changes were seen in speech of an undrugged partner. Dose-related increases were also obtained on an adjective checklist measuring characteristic opiate signs and symptoms. The relationship between behavioral, subjective, and reinforcing drug effects is discussed.

AB - The present study provides an objective assessment of the increased talkativeness associated with acute opiate drug administration. Speech of five methadone-maintenance subjects was recorded continuously for 1 h following the injection of 0, 10, 14, or 18 mg hydromorphone. Dose-related increases in subjects' speech were observed, while no systematic changes were seen in speech of an undrugged partner. Dose-related increases were also obtained on an adjective checklist measuring characteristic opiate signs and symptoms. The relationship between behavioral, subjective, and reinforcing drug effects is discussed.

KW - Behavioral effects

KW - Drug abusers

KW - Drug reinforcement

KW - Human speech

KW - Hydromorphone

KW - Opiate drugs

KW - Subjective effects

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Hydromorphone effects on human conversational speech

Abstract

Keywords

ASJC Scopus subject areas

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