Hydrodynamic properties and structure of the rat liver 12 S arginyl- and lysyl-tRNA synthetase complex

Chuan V. Dang, Chi V. Dang

Research output: Contribution to journalArticlepeer-review

Abstract

Eukaryotic aminoacyl-tRNA synthetases occur in multienzyme complexes in contrast to their prokaryotic counterparts. A core 12 S rat liver complex (Mr 290,000) was recently purified to homogeneity consisting of two polypeptides with Mr 73,000 and 65,000 identified as lysyl- and arginyl-tRNA synthetase, respectively (Dang et al. (1982) Biochemistry 21, 1959-1966). Using the modified hydrodynamic theory of Kirkwood (Kirkwood, J.R. (1954) J. Polym. Sci. 12,1-14), we have determined that the model most consistent with the hydrodynamic properties of the 12 S complex is a tetrameric tetrahedral model.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume117
Issue number2
DOIs
StatePublished - Dec 16 1983

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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