Hydrocephalus as a sequela of experimental myxovirus infections

Richard T. Johnson; Kenneth P. Johnson

doi:10.1016/0014-4800(69)90049-5

Hydrocephalus as a sequela of experimental myxovirus infections

Richard T. Johnson, Kenneth P. Johnson

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Suckling hamsters and mice were inoculated intracerebrally with several human myxoviruses. Mumps virus and parainfluenza-2 (croup-associated) virus were shown to infect ependymal cells in hamsters; this acute infection did not cause clinically apparent disease but resulted in the loss of ependymal cells. Influenza-A virus caused infection of ependymal cells in both hamsters and mice in which antigen developed, but no infectious virus multiplication was found; nevertheless, similar ependymal cell loss ensued. Following this selective destruction of the ependymal cell population by either mechanism, narrowing of the aqueduct of Sylvius evolved in most animals resulting in the development of severe hydrocephalus. The noninflammatory aqueductal stenosis showed several histological similarities to human aqueductal stenosis of obscure etiology. The possibility of acute infections causing noninflammatory yet progressive sequelae is discussed.

Original language	English (US)
Pages (from-to)	68-80
Number of pages	13
Journal	Experimental and Molecular Pathology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/0014-4800(69)90049-5
State	Published - Feb 1969
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Clinical Biochemistry

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title = "Hydrocephalus as a sequela of experimental myxovirus infections",

abstract = "Suckling hamsters and mice were inoculated intracerebrally with several human myxoviruses. Mumps virus and parainfluenza-2 (croup-associated) virus were shown to infect ependymal cells in hamsters; this acute infection did not cause clinically apparent disease but resulted in the loss of ependymal cells. Influenza-A virus caused infection of ependymal cells in both hamsters and mice in which antigen developed, but no infectious virus multiplication was found; nevertheless, similar ependymal cell loss ensued. Following this selective destruction of the ependymal cell population by either mechanism, narrowing of the aqueduct of Sylvius evolved in most animals resulting in the development of severe hydrocephalus. The noninflammatory aqueductal stenosis showed several histological similarities to human aqueductal stenosis of obscure etiology. The possibility of acute infections causing noninflammatory yet progressive sequelae is discussed.",

author = "Johnson, {Richard T.} and Johnson, {Kenneth P.}",

note = "Funding Information: {\textquoteright} This work was supported by grant 444 from the Multiple Sclerosis Society. {\textquoteright} Recipient of Special Fellowship eases and Blindness.",

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doi = "10.1016/0014-4800(69)90049-5",

language = "English (US)",

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T1 - Hydrocephalus as a sequela of experimental myxovirus infections

AU - Johnson, Richard T.

AU - Johnson, Kenneth P.

N1 - Funding Information: ’ This work was supported by grant 444 from the Multiple Sclerosis Society. ’ Recipient of Special Fellowship eases and Blindness.

PY - 1969/2

Y1 - 1969/2

N2 - Suckling hamsters and mice were inoculated intracerebrally with several human myxoviruses. Mumps virus and parainfluenza-2 (croup-associated) virus were shown to infect ependymal cells in hamsters; this acute infection did not cause clinically apparent disease but resulted in the loss of ependymal cells. Influenza-A virus caused infection of ependymal cells in both hamsters and mice in which antigen developed, but no infectious virus multiplication was found; nevertheless, similar ependymal cell loss ensued. Following this selective destruction of the ependymal cell population by either mechanism, narrowing of the aqueduct of Sylvius evolved in most animals resulting in the development of severe hydrocephalus. The noninflammatory aqueductal stenosis showed several histological similarities to human aqueductal stenosis of obscure etiology. The possibility of acute infections causing noninflammatory yet progressive sequelae is discussed.

AB - Suckling hamsters and mice were inoculated intracerebrally with several human myxoviruses. Mumps virus and parainfluenza-2 (croup-associated) virus were shown to infect ependymal cells in hamsters; this acute infection did not cause clinically apparent disease but resulted in the loss of ependymal cells. Influenza-A virus caused infection of ependymal cells in both hamsters and mice in which antigen developed, but no infectious virus multiplication was found; nevertheless, similar ependymal cell loss ensued. Following this selective destruction of the ependymal cell population by either mechanism, narrowing of the aqueduct of Sylvius evolved in most animals resulting in the development of severe hydrocephalus. The noninflammatory aqueductal stenosis showed several histological similarities to human aqueductal stenosis of obscure etiology. The possibility of acute infections causing noninflammatory yet progressive sequelae is discussed.

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Hydrocephalus as a sequela of experimental myxovirus infections

Abstract

ASJC Scopus subject areas

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