Hybridization of somatic cells derived from mouse and Syrian hamster: Evolution of karyotype and enzyme studies

Research output: Contribution to journalArticlepeer-review

Abstract

Somatic hybrids of drug-resistant mutant hamster and mouse cell lines have been isolated and propagated in long-term culture and have been studied in respect to karyotype and three enzymes. During the course of propagation the long-surviving hybrid clones show progressive loss of telocentric chromosomes associated in at least one case with loss of mouse enzyme. Hybrid clones showed hybrid molecules for malate dehydrogenase (MDH), lactate dehydrogenase (LDH), and 6-phosphogluconate dehydrogenase (6PGD) made up by recombination of parental subunits.

Original languageEnglish (US)
Pages (from-to)305-322
Number of pages18
JournalBiochemical Genetics
Volume1
Issue number4
DOIs
StatePublished - Mar 1 1968
Externally publishedYes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint

Dive into the research topics of 'Hybridization of somatic cells derived from mouse and Syrian hamster: Evolution of karyotype and enzyme studies'. Together they form a unique fingerprint.

Cite this