Abstract
Somatic hybrids of drug-resistant mutant hamster and mouse cell lines have been isolated and propagated in long-term culture and have been studied in respect to karyotype and three enzymes. During the course of propagation the long-surviving hybrid clones show progressive loss of telocentric chromosomes associated in at least one case with loss of mouse enzyme. Hybrid clones showed hybrid molecules for malate dehydrogenase (MDH), lactate dehydrogenase (LDH), and 6-phosphogluconate dehydrogenase (6PGD) made up by recombination of parental subunits.
Original language | English (US) |
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Pages (from-to) | 305-322 |
Number of pages | 18 |
Journal | Biochemical Genetics |
Volume | 1 |
Issue number | 4 |
DOIs | |
State | Published - Mar 1968 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Biochemistry