Hybrid Therapy for Spinal Metastases

Robert Rothrock, Zach Pennington, Jeff Ehresman, Mark H. Bilsky, Ori Barzilai, Nicholas J. Szerlip, Daniel M. Sciubba

Research output: Contribution to journalReview article


The combination of separation surgery and stereotactic body radiotherapy optimizes the treatment of metastatic spine tumors. The integration of SBRT into treatment paradigms produces superb local control rates and consequently has diminished the role of surgery from principle treatment to one of adjuvant therapy. Under this paradigm, hybrid therapy for the treatment of metastatic spine tumors employs separation surgery to decompress the spinal cord and stabilize the spine while creating a safe target for ablative SBRT. Hybrid therapy is well tolerated, allows an early return to systemic therapy, and provides durable, local tumor control compared with more aggressive traditional approaches.

Original languageEnglish (US)
JournalNeurosurgery clinics of North America
StateAccepted/In press - Jan 1 2020



  • Hybrid therapy
  • Metastases
  • Radiation
  • Radiosurgery
  • Separation surgery
  • Spinal cord
  • Spine
  • Tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Rothrock, R., Pennington, Z., Ehresman, J., Bilsky, M. H., Barzilai, O., Szerlip, N. J., & Sciubba, D. M. (Accepted/In press). Hybrid Therapy for Spinal Metastases. Neurosurgery clinics of North America. https://doi.org/10.1016/j.nec.2019.11.001