Hybrid lipids, peptides, and lymphocytes

new era in type 1 diabetes research

Abdel R Hamad, Mohanraj Sadasivam, Hamid Rabb

Research output: Contribution to journalArticle

Abstract

Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing β cells in islets of Langerhans. Many genetic and immunological insights into autoimmune disease pathogenesis were initially uncovered in the context of T1D and facilitated by preclinical studies using the nonobese diabetic (NOD) mouse model. Recently, the study of T1D has led to the discovery of fatty acid esters of hydroxyl fatty acids (FAHFAs), which are naturally occurring hybrid peptides that modulate inflammation and diabetes pathogenesis, and a hybrid lymphocyte that expresses both B and T cell receptors. Palmitic acid esters of hydroxy stearic acids (PAHSAs) are the most extensively studied FAHFA. In this issue of the JCI, Syed et al. have shown that PAHSAs both attenuate autoimmune responses and promote β cell survival in NOD mice. Given the lack of effective T1D therapies and the paucity of known side effects of PAHSAs, this lipid may have therapeutic potential for individuals at risk for or newly diagnosed with T1D.

Original languageEnglish (US)
JournalThe Journal of clinical investigation
Volume130
DOIs
StatePublished - Aug 5 2019

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Type 1 Diabetes Mellitus
Stearic Acids
Esters
Lymphocytes
Palmitic Acid
Lipids
Fatty Acids
Peptides
Inbred NOD Mouse
Research
Hydroxyl Radical
T-Cell Antigen Receptor
Autoimmunity
Islets of Langerhans
Autoimmune Diseases
Cell Survival
B-Lymphocytes
Insulin
Inflammation
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hybrid lipids, peptides, and lymphocytes : new era in type 1 diabetes research. / Hamad, Abdel R; Sadasivam, Mohanraj; Rabb, Hamid.

In: The Journal of clinical investigation, Vol. 130, 05.08.2019.

Research output: Contribution to journalArticle

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