Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Xin Lin, Jin Xie, Lei Zhu, Seulki Lee, Gang Niu, Ying Ma, Kwangmeyung Kim, Xiaoyuan Chen

Research output: Contribution to journalArticle

Abstract

Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.

Original languageEnglish (US)
Pages (from-to)1569-1572
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number7
DOIs
StatePublished - Feb 11 2011
Externally publishedYes

Fingerprint

Ferritins
Tumors
Chemical activation
Nanoparticles
Proteins
Imaging techniques
Scaffolds (biology)
Matrix Metalloproteinases
Heterografts
Scaffolds
Self assembly
Peptide Hydrolases
Metalloproteases

Keywords

  • ferritin
  • fluorescent probes
  • imaging agents
  • metalloenzymes
  • nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Hybrid ferritin nanoparticles as activatable probes for tumor imaging. / Lin, Xin; Xie, Jin; Zhu, Lei; Lee, Seulki; Niu, Gang; Ma, Ying; Kim, Kwangmeyung; Chen, Xiaoyuan.

In: Angewandte Chemie - International Edition, Vol. 50, No. 7, 11.02.2011, p. 1569-1572.

Research output: Contribution to journalArticle

Lin, Xin ; Xie, Jin ; Zhu, Lei ; Lee, Seulki ; Niu, Gang ; Ma, Ying ; Kim, Kwangmeyung ; Chen, Xiaoyuan. / Hybrid ferritin nanoparticles as activatable probes for tumor imaging. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 7. pp. 1569-1572.
@article{d17f5965bf874f4c99cfb13eb752cc56,
title = "Hybrid ferritin nanoparticles as activatable probes for tumor imaging",
abstract = "Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.",
keywords = "ferritin, fluorescent probes, imaging agents, metalloenzymes, nanoparticles",
author = "Xin Lin and Jin Xie and Lei Zhu and Seulki Lee and Gang Niu and Ying Ma and Kwangmeyung Kim and Xiaoyuan Chen",
year = "2011",
month = "2",
day = "11",
doi = "10.1002/anie.201006757",
language = "English (US)",
volume = "50",
pages = "1569--1572",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

TY - JOUR

T1 - Hybrid ferritin nanoparticles as activatable probes for tumor imaging

AU - Lin, Xin

AU - Xie, Jin

AU - Zhu, Lei

AU - Lee, Seulki

AU - Niu, Gang

AU - Ma, Ying

AU - Kim, Kwangmeyung

AU - Chen, Xiaoyuan

PY - 2011/2/11

Y1 - 2011/2/11

N2 - Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.

AB - Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.

KW - ferritin

KW - fluorescent probes

KW - imaging agents

KW - metalloenzymes

KW - nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=79851476422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79851476422&partnerID=8YFLogxK

U2 - 10.1002/anie.201006757

DO - 10.1002/anie.201006757

M3 - Article

C2 - 21308906

AN - SCOPUS:79851476422

VL - 50

SP - 1569

EP - 1572

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 7

ER -